{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:39Z","timestamp":1740124359459,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["PAPIIT TA 200318"],"award-info":[{"award-number":["PAPIIT TA 200318"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["FOSISS SALUD\u20102015\u201001\u2010261317"],"award-info":[{"award-number":["FOSISS SALUD\u20102015\u201001\u2010261317"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Reliable methods for the quantitative evaluation of skin of patients with ichthyosis are critically needed. Our purpose was to evaluate the biomechanical parameters of skin in a cohort of patients with clinically diagnosed lamellar ichthyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Twenty\u2010two patients diagnosed with lamellar ichthyosis were studied. Ichthyosis plaques located in upper distal limbs were assayed, and a nearby anatomical region without plaques from the same patient was employed as control. Skin biomechanical properties were studied through a non\u2010invasive device (Cutometer<jats:sup>\u00ae<\/jats:sup> <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> 580).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ichthyosis plaques had higher values for the Uf\u2010Ua parameter and lower values for the Ua\/Uf, Ur\/Ue, and Ur\/Uf parameters. Adults and children showed similar statistical differences. There were no significant differences in data from men, whereas in women differences for all of the parameters were found. There was a significant decrease in the hydration and an increase in melanin index in the ichthyosis plaques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that analysis of parameters Uf\u2010Ua, Ua\/Uf, Ur\/Ue, Ur\/Uf, hydration, and melanin index could be employed for quantitative monitoring of skin. Therefore, the non\u2010invasive method applied may be suitable for evaluation of skin of patients with ichthyosis in response to medical treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12663","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T11:39:31Z","timestamp":1546429171000},"page":"375-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Non\u2010invasive analysis of skin mechanical properties in patients with lamellar ichthyosis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-4109","authenticated-orcid":false,"given":"Hern\u00e1n","family":"Cort\u00e9s","sequence":"first","affiliation":[{"name":"Laboratorio de Medicina Gen\u00f3mica Departamento de Gen\u00e9tica Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4399-4618","authenticated-orcid":false,"given":"Jonathan J.","family":"Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Gen\u00f3mica Departamento de Gen\u00e9tica Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Octavio D.","family":"Reyes\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular del C\u00e1ncer UMIEZ Facultad de Estudios Superiores Zaragoza Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9","family":"Zacaula\u2010Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina Instituto Polit\u00e9cnico Nacional  Ciudad de M\u00e9xico M\u00e9xico"},{"name":"Laboratorio de Tejido Conjuntivo Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3899-4410","authenticated-orcid":false,"given":"Maykel","family":"Gonz\u00e1lez\u2010Torres","sequence":"additional","affiliation":[{"name":"Conacyt\u2010Laboratorio de Biotecnolog\u00eda Instituto Nacional de Rehabilitaci\u00f3n \u201cLu\u00eds Guillermo Ibarra Ibarra\u201d  Ciudad de Mexico M\u00e9xico"},{"name":"Instituto Tecnol\u00f3gico y de Estudios Superiores de Monterrey  Campus Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Diaz\u2010Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad Veracruzana  Ciudad Mendoza M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda C.","family":"Le\u00f3n\u2010Trejo","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n M\u00e9dica Instituto Mexicano del Seguro Social  Orizaba M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizbeth","family":"Cari\u00f1o\u2010Calvo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas Universidad Veracruzana  Orizaba M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Leyva\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6346-3174","authenticated-orcid":false,"given":"Manuel","family":"Gonz\u00e1lez\u2010Del Carmen","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad Veracruzana  Ciudad Mendoza M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0313-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.11.020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13243"},{"key":"e_1_2_8_5_1","unstructured":"GeneReviews\u00ae [Internet].Autosomal Recessive Congenital Ichthyosis.https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1420\/. 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