{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:20:28Z","timestamp":1777929628627,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patch testing is the gold standard for evaluating allergic contact dermatitis (<jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>), yet current interpretation methods are limited by their subjectivity and possible variability between observers. Optical coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) imaging enables noninvasive in vivo skin visualization and holds promise as an objective method of patch test interpretation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the micromorphological changes of patch test reactions and identify objective, quantitative <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> markers that correlate with clinically graded patch test reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 25 patch test reactions (7 grade\u20100, 4 grade\u20101+, 14 grade\u20102+) from 7 patients underwent <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> evaluation. Increased epidermal thickness and density was qualitatively observed in grade 1+ and grade 2+ allergic reactions while well\u2010demarcated, signal\u2010free cavities were observed in all grade 2+ reactions. Attenuation coefficients significantly increased across the three reaction grades (2.58\u00a0\u00b1\u00a00.092, 2.96\u00a0\u00b1\u00a00.121, 3.05\u00a0\u00b1\u00a00.065; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Cutaneous blood flow at 0.35\u00a0mm monotonically increased with reaction grade severity and blood measurements significantly differed across the three reaction grades (0.053\u00a0\u00b1\u00a00.011\u00a0mm\/s, 0.078\u00a0\u00b1\u00a00.015\u00a0mm\/s, and 0.121\u00a0\u00b1\u00a00.008\u00a0mm\/s; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Attenuation coefficient and cutaneous blood flow at 0.35\u00a0mm correlate with clinically graded patch test reactions and hold promise as objective, quantitative markers. <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> may help dermatologists differentiate clinical scoring of allergic reactions in patch test and thereby improve their diagnostic accuracy and interpretation of patch test reactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12695","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T02:01:39Z","timestamp":1553047299000},"page":"625-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of positive patch test reactions using optical coherence tomography: A pilot study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-9844","authenticated-orcid":false,"given":"Ali","family":"Rajabi\u2010Estarabadi","sequence":"first","affiliation":[{"name":"Dr.Phillip Frost Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6409-7070","authenticated-orcid":false,"given":"Darren C.","family":"Tsang","sequence":"additional","affiliation":[{"name":"Dr.Phillip Frost 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