{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:24:43Z","timestamp":1788020683715,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010pulsed (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>) lasers at pulse durations of 1\u2010300\u00a0ms have been used to destroy nests of nevi cells by selectively targeting pigment chromophores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate dual\u2010wavelength <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> laser\u2010induced tissue reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patterns of <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> 755\u2010nm alexandrite (Alex) and\/or 1064\u2010nm neodymium (Nd):yttrium\u2010aluminum\u2010garnet (<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>) laser\u2010induced tissue reactions were macroscopically evaluated using a tattoo\u2010embedded phantom. Additionally, a pilot in vivo human study was performed for common acquired melanocytic nevus, of which dermoscopic images and high\u2010speed cinematographs were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Combinations of Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> and Alex laser treatments at interpulse intervals of 10 or 20\u00a0ms generated round to oval zones of photothermal and photoacoustic injury in two distinctive areas containing disintegrated tattoo particles. Treatment at interpulse intervals of 10 or 20\u00a0ms between Alex and Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> pulses elicited lesser degrees of thermal damage to surrounding tissues, compared to treatment at 100 or 200\u00a0ms. Immediately after combined <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> laser treatment of human nevus lesions in vivo, Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>\u2010Alex treatment at a 20\u2010ms interpulse interval exhibited more remarkable crusting and erosive appearances than Alex\u2010Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For treating pigmented disorders, sequential delivery of <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> and Alex pulses at short interpulse intervals of 10\u201020\u00a0ms can effectively destroy nests of pigment chromophores.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12704","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T19:53:39Z","timestamp":1557172419000},"page":"683-692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sequential delivery of long\u2010pulsed 755\u2010nm alexandrite laser and long\u2010pulsed 1,064\u2010nm neodymium:yttrium\u2010aluminum\u2010garnet laser treatment for pigmented disorders"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-5071","authenticated-orcid":false,"given":"Sung Bin","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Center International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon Korea"},{"name":"Yonsei Seran Dermatology and Laser Clinic Seoul 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