{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:02:07Z","timestamp":1747188127955,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T00:00:00Z","timestamp":1557619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Analytical measures for the pharmacodynamics understanding of drug induced scalp hair responses are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The present study measured in detail dynamics of hair productivity on two scalp test sites showing male pattern hair loss. The natural regression decay rate established after 2\u00a0years without treatment was followed by treatment with daily oral intake of 1\u00a0mg finasteride.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>While terminal hair (diameter \u226540\u00a0\u03bcm) were maintained \u201con\u2010drug,\u201d within 30\u00a0months \u201coff\u2010drug\u201d MPHL significantly worsened as 94% terminal hair miniaturised and became unproductive. Accordingly, the viable drug responding follicles were qualified as \u201cfinasteride dependent\u201d unravelling a hereto unreported \u201crebound effect\u201d after interruption of the drug intake. Interestingly, the transformation of terminal hair into miniaturised hair occurred only after 12\u00a0months without treatment, that is the time necessary to complete a clinically significant full hair cycle initiated during the drug intake. This explains why exogen hair release and miniaturisation occurred only between 12 and 30\u00a0months \u201coff\u2010drug\u201d while resistant hair grew also slower.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Drug dependency and rebound phenomenon are new findings along with evidence against the hypothesis claiming that terminal hair growth arises from initial vellus hair follicles in drug\u2010treated MPHL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12707","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T06:21:51Z","timestamp":1557728511000},"page":"712-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Maintenance of optimised hair growth from viable terminal scalp hair follicles at baseline with oral finasteride in male pattern hair loss and first evidence of a \u201cdrug dependency\u201d and a post\u2010finasteride \u201crebound 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