{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:30:38Z","timestamp":1782563438279,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The early detection of skin cancer is still challenging and calls for objective, fast diagnostic, and ideally non\u2010invasive methods in order to leave the potentially malignant tumor cells unaltered. In this paper, the parelectric spectroscopy was applied to evaluate the potential of a non\u2010invasive detection of basal cell carcinoma (BCC) and malignant melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A prototype of parelectric spectroscopy was used to investigate non\u2010invasively dipole density and mobility of suspicious skin lesions. The differences in investigated tissue were analyzed compared to pathohistological findings in a clinical study on 51 patients with suspected BCC and malignant melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The non\u2010invasive parelectric spectroscopy could differentiate between normal skin, BCC, and melanoma but failed to distinguish between different types of skin cancer. The data were normalized to unsuspected nearby skin because the different skin locations influence dipole density and mobility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of the pilot study indicate that the parelectric spectroscopy might be an additional, useful non\u2010invasive diagnostic procedure to distinguish between normal skin and skin cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12785","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T10:24:23Z","timestamp":1569320663000},"page":"234-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Application of parelectric spectroscopy to detect skin cancer\u2014A pilot study"],"prefix":"10.1111","volume":"26","author":[{"given":"Frederike S.","family":"Arnold\u2010Br\u00fcning","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology Center of Experimental and Applied Cutaneous Physiology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Blaschke","sequence":"additional","affiliation":[{"name":"Parelectrics Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kramer","sequence":"additional","affiliation":[{"name":"Parelectrics Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Lademann","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology Center of Experimental and Applied Cutaneous Physiology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Thiede","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology Center of Experimental and Applied Cutaneous Physiology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim W.","family":"Fluhr","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology Center of Experimental and Applied Cutaneous Physiology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin and Berlin Institute of Health Berlin 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