{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:29:41Z","timestamp":1788805781402,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Botulinum neurotoxin (BoNT) effectively downregulates the secretion of eccrine sweat glands in patients with axillary and palmoplantar primary hyperhidrosis (PH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To demonstrate the efficacy and safety of pressure\u2010 and dose\u2010controlled, needle\u2010free, transcutaneous pneumatic injection (TPI) of BoNT\u2010A for treating axillary and palmoplantar PH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Needleless TPI\u2010BoNT\u2010A treatments were delivered on the axillary or palmoplantar skin at a pneumatic pressure of 2.05 bars and an injection volume of 0.08\u00a0mL\/shot. The efficacy thereof was assessed by evaluating starch\u2010iodine test results and Hyperhidrosis Disease Severity Scale (HDSS) scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, median HDSS scores were 3 (IQR, 3\u20104) for axillary lesions and 4 (IQR, 3.5\u20104) for palmoplantar lesions. Median HDSS scores at 1\u00a0month after TPI\u2010BoNT\u2010A treatment significantly decreased to 1 (IQR, 1\u20101.75) for axillary lesions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and 1 (IQR, 1\u20102) for palmoplantar lesions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Median global improvement scale scores were 4 (IQR, 3.25\u20104) for axillary PH and 3 (IQR, 2.5\u20104) for palmoplantar PH (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). In all patients, pain was tolerable during treatments for both axillary and palmoplantar PH after the application of topical anesthetic cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pressure\u2010 and dose\u2010controlled, needle\u2010free, BoNT delivery effectively and safely decreased sweating in axillary and palmoplantar skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12835","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T12:36:17Z","timestamp":1578659777000},"page":"577-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pressure\u2010and dose\u2010controlled, needle\u2010free, transcutaneous pneumatic injection of botulinum neurotoxin\u2010A for the treatment of primary axillary and palmoplantar hyperhidrosis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9068-5813","authenticated-orcid":false,"given":"Hyoung Moon","family":"Kim","sequence":"first","affiliation":[{"name":"Maylin Clinic Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Yonsei E1 Plastic Surgery Clinic Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Bestop Clinic Laser Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwangheui","family":"Lee","sequence":"additional","affiliation":[{"name":"Cheongdam NB Clinic Seoul 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