{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:57:38Z","timestamp":1777399058868,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical and health technology innovation project of Chinese Academy of Medical Sciences","award":["2017-12M-3-020"],"award-info":[{"award-number":["2017-12M-3-020"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early\u2010stage pemphigus vulgaris (PV) often manifests as erythema alone. We hypothesized that very high\u2010frequency ultrasonography (VHFUS) features could simplify the differential diagnosis of early\u2010stage pemphigus vulgaris versus seborrheic dermatitis (SD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fourteen patients with SD or early\u2010stage PV were recruited from our outpatient clinic during 2016\u20102019. We used 50\u2010MHz VHFUS to image the erythema on the patients\u2019 scalp, face, chest, and back and retrospectively evaluated their ultrasonographic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Very high\u2010frequency ultrasonography images of early\u2010stage PV showed enhanced epidermal echo (8\/14, 57%), linear or oval intra\u2010epidermal hypoechoic\/anechoic areas (12\/14, 86%), linear anechoic areas at the dermal\u2010epidermal junction (14\/14, 100%), reduced echo of superficial to whole dermis (9\/14, 64%), and slightly increased dermal thickness (14\/14, 100%). The intra\u2010epidermal hypoechoic\/anechoic bands (100%) showed the greatest specificity. VHFUS images of SD showed enhanced epidermal echo (7\/14, 50%), epidermal unevenness (7\/14, 50%), linear anechoic bands at the dermal\u2010epidermal junction (8\/14, 57%), reduced middle dermis echo (10\/14, 71%), and slightly increased dermal thickness (10\/14, 71%). The epidermal unevenness (100%) had the greatest specificity. There was a significant difference (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) between early\u2010stage PV and SD regarding the proportion of linear intraepithelial hypoechoic\/anechoic bands and linear anechoic areas at the dermal\u2010epidermal junction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early\u2010stage PV and SD have relatively specific VHFUS erythematous manifestations. Intra\u2010epidermal hypoechoic\/anechoic bands for early\u2010stage PV and epidermal unevenness for SD were most specific. VHFUS contributes to the differential diagnosis of PV and SD by highlighting their features, that is, intra\u2010epidermal hypoechoic\/anechoic bands and linear anechoic areas at the dermal\u2010epidermal junction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12836","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T08:40:45Z","timestamp":1578904845000},"page":"476-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigation of using very high\u2010frequency ultrasound in the differential diagnosis of early\u2010stage pemphigus vulgaris vs seborrheic dermatitis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7652-9395","authenticated-orcid":false,"given":"Xiaofeng","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Beijing Union Medical College Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Beijing Union Medical College Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Beijing Union Medical College Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Beijing Union Medical College Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haimeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Beijing Union Medical College Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1686-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201302600425"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.06046"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.10.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medici.2014.08.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14211"},{"key":"e_1_2_8_8_1","first-page":"1305","article-title":"Ultrasound technologies for dermatologic applications","volume":"13","author":"Alexiades M","year":"2014","journal-title":"J DRUGS DERMATOL"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000054"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14278"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12836","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12836","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.12836","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T10:28:24Z","timestamp":1693823304000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,13]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/srt.12836"],"URL":"https:\/\/doi.org\/10.1111\/srt.12836","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,13]]},"assertion":[{"value":"2019-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}