{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:26:56Z","timestamp":1788200816092,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T00:00:00Z","timestamp":1592092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Facial erythema is a common symptom in rosacea. To overcome subjectivity in scoring erythema severity, objective redness quantification is desirable. This study evaluated an image\u2010based erythema quantification tool to monitor facial erythema in rosacea patients during treatment and compared these values to clinical scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010one rosacea patients were treated with topical ivermectin for 16\u00a0weeks. Clinical erythema scores and clinical photographs were taken at week 0, 6, 16 and 28. Using ImageJ, RGB images were split into red, green and blue channels to measure the green\/red ratio of lesional skin compared with a green sticker. With CIELAB colour space,\n                      <jats:italic>a*<\/jats:italic>\n                      (indicating colour from green to red) of a lesional and non\u2010lesional facial site was measured, calculating\n                      <jats:italic>\u2206a*<\/jats:italic>\n                      . Interobserver concordance and correlation between quantitative and clinical erythema values were determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Treatment resulted in reduction of clinical erythema scores. No significant changes in red\/green ratios were measured. Lesional\n                      <jats:italic>a*<\/jats:italic>\n                      and\n                      <jats:italic>\u2206a*<\/jats:italic>\n                      significantly decreased from baseline to week 16 and 28 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). A weak correlation existed between clinical scores and lesional\n                      <jats:italic>a*<\/jats:italic>\n                      (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a00.37), and between clinical scores and\n                      <jats:italic>\u2206a*<\/jats:italic>\n                      (\n                      <jats:italic>\n                        R\n                        <jats:sub>s<\/jats:sub>\n                      <\/jats:italic>\n                      \u00a0=\u00a00.30), with a clear trend towards higher\n                      <jats:italic>a*<\/jats:italic>\n                      and\n                      <jats:italic>\u2206a*<\/jats:italic>\n                      for higher clinical scores. Interobserver correlation was high (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.82).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      ImageJ is a simple, rapid, objective and reproducible tool to monitor erythema in rosacea patients during treatment. The photographs allow retrospective analysis, evaluation of large and small lesions, and discrimination of subtle redness differences. We recommend using lesional\n                      <jats:italic>a*<\/jats:italic>\n                      to monitor erythema of inflammatory dermatoses in clinical practice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.12878","type":"journal-article","created":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T21:55:27Z","timestamp":1592171727000},"page":"804-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Evaluation of a simple image\u2010based tool to quantify facial erythema in rosacea during treatment"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-0696","authenticated-orcid":false,"given":"Jade G. M.","family":"Logger","sequence":"first","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke M. G. J.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rieke J. B.","family":"Driessen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet E. J.","family":"van Erp","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.037"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2016.1157360"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.02.1121"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.04.013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.05.044"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12616156"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18151"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00256.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1562\/2005-08-02-TSN-635"},{"key":"e_1_2_7_11_1","first-page":"121","article-title":"Measurement of skin color: practical application and theoretical considerations","volume":"44","author":"Takiwaki H","year":"1998","journal-title":"J Med Invest"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12769"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12075"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12191"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29141.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/37\/3\/333"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13531"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2017.29.2.167"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12318"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10174.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02258.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17590"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00204.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31154-6"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60946-6_39"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2013.1931"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03169.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4815"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0909-752X.2006.00145.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12396"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.12878","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T17:38:49Z","timestamp":1693849129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,14]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/srt.12878"],"URL":"https:\/\/doi.org\/10.1111\/srt.12878","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,14]]},"assertion":[{"value":"2020-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}