{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:07:04Z","timestamp":1787594824779,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"TOOsonix A\/S"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin cancer is common, growing, challenging, and in need of progress in early\u2010stage treatment. 20 MHz high\u2010intensity focused ultrasound (HIFU) is new and applied to actinic keratosis (AK) and skin cancers for the first time. HIFU of lower frequency is already used in the treatment of internal cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Eight patients with 201 AK lesions, one patient with 7 basal cell carcinomas (reoccurrences after PDT), and one patient with 7 Kaposi sarcoma lesions (4 treated with radiotherapy in the past) were given 1\u20103 HIFU treatments. Twenty megahertz HIFU was dosed as 150\u00a0ms at 0.6\u20101.2\u00a0J\/shot applied to target lesions. Probes with different target depths were available. The preferred shot energy and focal depth in AK were 0.9\u00a0J and 1.3\u00a0mm. A \u201cSandwich\u201d strategy with HIFU applied in two depths were tried in cancers. The follow\u2010up period was 3\u20106\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All AK cleared except 5, giving a cure rate of 97%. Post\u2010treatment lesion healed in 1\u20102\u00a0weeks with no scar. VAS pain was from 1 to 8, and in any case less than experienced with previous PDT. In both basal cell carcinoma (BCC) and sarcoma, healing was confirmed by histological verification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion\/conclusion<\/jats:title><jats:p>20 MHz HIFU was an effective and safe treatment of AK. This new treatment, applicable to any anatomical site, has promising advantages relative to PDT and has the potential to replace or supplement PDT in future. Case\u2010observations indicated that HIFU can be useful in skin cancers as well.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12883","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T03:35:40Z","timestamp":1592451340000},"page":"824-831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["High\u2010frequency (20 MHz) high\u2010intensity focused ultrasound: New Treatment of actinic keratosis, basal cell carcinoma, and Kaposi sarcoma. An open\u2010label exploratory study"],"prefix":"10.1111","volume":"26","author":[{"given":"J\u00f8rgen","family":"Serup","sequence":"first","affiliation":[{"name":"Department of Dermatology Bispebjerg University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3918-1182","authenticated-orcid":false,"given":"Torsten","family":"Bove","sequence":"additional","affiliation":[{"name":"TOOsonix A\/S Horsholm Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Zawada","sequence":"additional","affiliation":[{"name":"TOOsonix A\/S Horsholm Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Jessen","sequence":"additional","affiliation":[{"name":"TOOsonix A\/S Horsholm Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Poli","sequence":"additional","affiliation":[{"name":"TOOsonix A\/S Horsholm Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Focused Ultrasound Foundation.State of the Field 2019.https:\/\/www.fusfoundation.org\/the\u2010foundation\/foundation\u2010reports#SOTF. 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Accessed January 5 2020."},{"key":"e_1_2_6_19_1","unstructured":"ZawadaT BoveT.Acoustic Device for Skin Treatment and Methods of Using the Same. Patent application WO 2018\/158355 A1."},{"key":"e_1_2_6_20_1","unstructured":"TOOsonix System ONE\u2010R system description. Available fromhttps:\/\/www.toosonix.com\/. 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