{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:15:44Z","timestamp":1790615744163,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Kligman\u2019s formula (KF) remains to date the dermatologists\u2019 treatment of choice for melasma. This study was aimed at the evaluation of the effectiveness of Modified Kligman\u2019s formula (MKF) in comparison with cysteamine 5% cream on the severity of epidermal melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 50 subjects with epidermal melasma were included in this double\u2010blind, randomized trial study. Subjects received either cysteamine 5% cream or an MKF (4% hydroquinone, 0.05% retinoic acid and 0.1% betamethasone). Cysteamine cream (applied once daily, 15\u00a0minutes exposure) or MKF (applied once daily, whole night exposure) were used by the subjects over four consecutive months. The efficacy of the treatments was determined through the modified Melasma Area Severity Index (mMASI) score, the Investigator\u2019s Global Assessment (IGA) and patient questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean (SD) age of the subjects was 34.96 (6.17) and 35.76 (5.23) years for cysteamine and MKF group, respectively. The mean mMASI score after 4\u00a0months was 7.04 (2.23) in the MKF group and 6.09 (2.01) in the cysteamine group. At both prospective evaluation points (2\u00a0months, 4\u00a0months), the percentage reduction in mMASI score was approximately 9% greater by cysteamine cream as compared to MKF, and these differences were statistically significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005 and .001 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cysteamine 5% cream showed greater efficacy as compared to MKF. It is thus proposed that cysteamine 5% cream is more effective than MKF in the treatment of melasma, with the advantage of being significantly better tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12901","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T20:59:07Z","timestamp":1593118747000},"page":"24-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Clinical evaluation of efficacy, safety and tolerability of cysteamine 5% cream in comparison with modified Kligman\u2019s formula in subjects with epidermal melasma: A randomized, double\u2010blind clinical trial study"],"prefix":"10.1111","volume":"27","author":[{"given":"Maryam","family":"Karrabi","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Sabzevar University of Medical Sciences Sabzevar Iran"},{"name":"Leishmaniosis Research Center Sabzevar University of Medical Sciences 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