{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:10:07Z","timestamp":1790719807508,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R01 NR03699"],"award-info":[{"award-number":["R01 NR03699"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infant diaper dermatitis (DD) is a prevalent condition due to multiple, interactive factors including increased skin hydration, irritant exposure, and increased skin pH. We examined diaper dermatitis vs within diaper and non\u2010diaper controls over time and characterized the association of skin color and texture relative to skin barrier integrity, hydration, and pH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The prospective study included 46 infants with DD at well\u2010child visits. Skin integrity was evaluated over 15\u00a0days, including visual skin condition, rate of stratum corneum transepidermal water accumulation, hydration, pH, and skin color and texture from high\u2010resolution digital skin surface images. Effects by site and time were evaluated with general linear models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six distinct texture patterns were observed. All three sites differed significantly for texture class frequency. Normal dermatoglyphics were more frequent for non\u2010diaper vs both within diaper and rash sites. Dermatoglyphics with marked furrows or lines (class 3) were common within diaper vs rash but not for non\u2010diaper vs within diaper. Streaks were highest for DD and lowest for non\u2010diaper. Flat regions were more frequent DD. Barrier integrity, that is, moisture accumulation rate, was lower for normal dermatoglyphics than streaks or flat texture. DD severity decreased over 15\u00a0days. Barrier properties of within diaper and non\u2010diaper areas were not well\u2010differentiated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of streak texture in the within diaper high magnification images was high despite being visually normal. This finding suggests that it is an \u201cearly indicator\u201d of skin damage and may be clinically useful for early detection and treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12925","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T09:29:52Z","timestamp":1594978192000},"page":"145-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Imaging reveals distinct textures at three infant skin sites and reflects skin barrier status"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9266-4127","authenticated-orcid":false,"given":"Marty","family":"O Visscher","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati OH USA"},{"name":"College of Medicine University of Cincinnati Cincinnati OH 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