{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:37:56Z","timestamp":1789609076313,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Reflectance confocal microscopy (RCM) is a useful tool for many skin cancers, allowing non\u2010invasive evaluation over time and identifying areas of active disease. Its role to follow\u2010up mycosis fungoides (MF) patients has not yet been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the level of agreement between RCM and histopathology and to develop a RCM checklist that could help monitoring MF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Prospective study in a cutaneous lymphoma clinic of a tertiary hospital in Australia. RCM and biopsies were performed on the same area at baseline, before commencing or changing treatment, and at 6\u00a0months after starting treatment. Normal skin sites were also analysed and acted as controls. RCM features and histopathological findings were blindly evaluated by the confocalist and pathologist. Correlation between RCM and histology was measured by overall per cent of agreement (OPA), kappa and ROC curves. Additionally, RCM images before and after treatment were assessed blinded from clinical information and correlated to clinical assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight MF lesions were included. Nineteen of these 38 were re\u2010assessed by RCM 6\u00a0months later. Fifty biopsies were performed (38 at baseline and 12 after 6\u00a0months). The combination of four RCM features corresponding to Pautrier's microabscess, epidermal and junctional lymphocytes and interface dermatitis formed the RCM checklist for MF that predicted the severity of disease with AUC of 0.95 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reflectance confocal microscopy can assess activity within a lesion and over time and assist in the clinical management of patients with MF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12967","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T07:33:10Z","timestamp":1603524790000},"page":"414-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Reflectance confocal microscopy role in mycosis fungoides 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Alta Tecnologia Diagnostica\u2010Dermatologia  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Fernandez\u2010Penas","sequence":"additional","affiliation":[{"name":"Sydney Medical School The University of Sydney  Sydney NSW Australia"},{"name":"Department of Dermatology Westmead Hospital  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032810"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt242"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-21997-9"},{"issue":"5","key":"e_1_2_8_5_1","first-page":"446","article-title":"Confocal microscopy patterns in nonmelanoma skin cancer and clinical applications","volume":"105","author":"Gonzalez S","year":"2014","journal-title":"Actas 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