{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T10:51:56Z","timestamp":1769338316043,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671743"],"award-info":[{"award-number":["81671743"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While uncomplicated cases of skin squamous cell carcinoma (cSCC) can be treated with surgery topical therapy alone, more objective and non\u2010invasive examination methods are needed to guide clinicians to make more detailed biopsy and surgical plans for lesions with atypical or subcutaneous growth. High\u2010resolution magnetic resonance imaging (HR\u2010MRI) is a novel skin imaging method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Prospective collection of 19 patients with clinically suspected cSCC. All patients underwent high\u2010resolution DCE\u2010MRI using a 70\u2010mm microscopy coil before operation. The imaging features and results of surgical pathology were recorded. <jats:italic>K<\/jats:italic><jats:sup>trans<\/jats:sup>, <jats:italic>K<\/jats:italic><jats:sub>ep<\/jats:sub>, <jats:italic>V<\/jats:italic><jats:sub>e<\/jats:sub> values, and the time\u2010signal curve (TIC) types were determined using DCE images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>16 cases of cSCC, 3 cases of acanthoma. The subcutaneous invasion of all lesions was clearly displayed, of which 8 lesions invaded the subcutaneous fat layer, 5 invaded the muscle layer, 1 invaded the periosteum, 2 invaded the cap fascia, and the layer of all lesions invasion judged by HR\u2010MR imaging was consistent with the postoperative pathology. The main manifestations of cSCC were ill\u2010defined margin, obvious inhomogeneous enhancement, higher perfusion parameters value and type\u2010III TIC, while acanthoma showed well\u2010defined and type\u2010I TIC. Some imaging findings (such as boundary, enhancement) and DCE perfusion parameters of the two groups overlap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010resolution DCE\u2010MRI can fully and directly display the subcutaneous invasion of cSCC, and more work needs to be done to prove its value. Next, we will expand the sample size, and further explore its value in the differential diagnosis and prognosis evaluation of cSCC from acanthoma or other skin tumors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12978","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T19:03:10Z","timestamp":1604430190000},"page":"511-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical value of high\u2010resolution dynamic contrast\u2010enhanced (DCE) MRI in diagnosis of cutaneous squamous cell carcinoma"],"prefix":"10.1111","volume":"27","author":[{"given":"Mengxiao","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Radiology the First Affiliated Hospital of Soochow University Suzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renjun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology the First Affiliated Hospital of Soochow University Suzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology the First Affiliated Hospital of Soochow University Suzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiying","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery the First Affiliated Hospital of Soochow University Suzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongshuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Siemens Healthcare Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianming","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Radiology the First Affiliated Hospital of Soochow University Suzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingchuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology the First Affiliated Hospital of Soochow University Suzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-3094","authenticated-orcid":false,"given":"Yonggang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology the First Affiliated Hospital of Soochow University Suzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Optical coherence tomography for diagnosing skin cancer in adults","volume":"12","author":"Ferrante DRL","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"40","article-title":"Non\u2010melanoma skin cancer\u2014a clinicopathological study of patients with basal cell carcinoma and squamous cell carcinoma","volume":"31","author":"Barto\u0161 V","year":"2017","journal-title":"Klin Onkol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2010.0062"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0367-4"},{"key":"e_1_2_8_6_1","article-title":"High\u2010frequency ultrasound for diagnosing skin cancer in adults","volume":"12","author":"Dinnes J","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_7_1","first-page":"22","article-title":"Confocal microscopy and other non\u2010invasive tools for the diagnosis of non\u2010melanoma skin cancers and other skin conditions","volume":"218","author":"Malvehy J","year":"2017","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.10.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2015.1221"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2015140142"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01676830701558166"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181b4c0cf"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2019.01.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1348-z"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-5050-2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-019-02234-6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2018.04.004"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26607"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-018-1543-y"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.10.010"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.01.009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.08.051"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12371"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2004.06.018"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2013.14.2.287"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0703a07"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2018.04.05"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.10.028"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170707"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12978","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.12978","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T22:06:59Z","timestamp":1693346819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,3]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/srt.12978"],"URL":"https:\/\/doi.org\/10.1111\/srt.12978","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,3]]},"assertion":[{"value":"2020-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}