{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:00:37Z","timestamp":1790424037096,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The quest for diagnostic tools for the detection of cutaneous malignant melanoma (cMM) is ongoing. A challenge in cMM care is not overlooking cMM at an early stage, while simultaneously avoiding unnecessary biopsies or excisions of benign pigmented skin lesions (PSLs). A novel hyperspectral imaging (HSI) device is shown to have potential for differentiating equivocal PSLs in Asian skin types. Our objective was to assess the accuracy of the HSI device in distinguishing between cMM and benign PSLs in patients with Caucasian skin types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with Caucasian skin types (Fitzpatrick I\u2010II), enrolled for excisional biopsies of PSLs were included and examined using the HSI device. The discrimination index (DI) was used to demonstrate the sensitivity (SE) and specificity (SP) in comparison with the re\u2010evaluated histopathology diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 186 patients, 202 pigmented skin lesions were included. The sensitivity to detect cMM was 96.7% (87\/90), and the specificity for benign lesions was 42.1% (45\/107). The AUC was 0.800 (95% confidence interval (CI): 0.740\u20100.861).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our novel HSI device showed a high sensitivity in detecting malignant lesions in patients with Caucasian skin types. Compared with analogous technologies, as multispectral imaging or electrical impedance spectroscopy, our device showed similar or better accuracy in differentiating cMM from benign PSLs. Therefore, it might be a useful clinical tool in skin types I\u2010IV and where further triage of pigmented skin lesions is important.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13023","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T10:53:52Z","timestamp":1614682432000},"page":"803-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical performance of a novel hyperspectral imaging device for cutaneous melanoma and pigmented skin lesions in Caucasian skin"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6797-1301","authenticated-orcid":false,"given":"Gustav Boelsgaard","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Dermatology Skane University Hospital Lund University Lund Sweden"},{"name":"Department of Clinical Sciences Lund, Dermatology Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7460-5008","authenticated-orcid":false,"given":"Takashi","family":"Nagaoka","sequence":"additional","affiliation":[{"name":"Department of Computational System Biology Kindai University Kinokawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Kiyohara","sequence":"additional","affiliation":[{"name":"Dermatology Division Shizuoka Cancer Center Hospital Nagaizumi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Pathology Skane University Hospital Lund University Lund Sweden"},{"name":"Department of Clinical Sciences Lund, Pathology Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ingvar","sequence":"additional","affiliation":[{"name":"Department of Surgery Skane University Hospital Lund University Lund Sweden"},{"name":"Department of Clinical Sciences Lund, Surgery Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Waseda Research Institute for Science and Engineering Waseda University Shinjuku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Sota","sequence":"additional","affiliation":[{"name":"Waseda Research Institute for Science and Engineering Waseda University Shinjuku Japan"},{"name":"Department of Electrical Engineering and Bioscience Waseda University Shinjuku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Skane University Hospital Lund University Lund Sweden"},{"name":"Department of Clinical Sciences Lund, Dermatology Lund University Lund 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