{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:02:46Z","timestamp":1747188166438,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010frequency ultrasound (HFUS) using a 20\u00a0MHz probe is a non\u2010invasive assessment tool. Its utility in dermatology for diagnosis of disease or for monitoring of treatment response in various dermatological conditions is still being explored. Edema secondary to venous hypertension is the main pathogenic factor in the development of venous leg ulcers. However, there is no objective method for assessment of degree of edema. In this study, we explore the utility of high\u2010frequency ultrasound in assessing cutaneous edema and for monitoring its improvement with compression therapy among patients with venous ulcer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty patients with venous ulcer were enrolled in the study. Measurement of cutaneous edema was done at baseline and after 2\u00a0weeks of compression therapy in all patients. The 3 levels of measurement were dorsum of foot (low site, L1), 4\u00a0cm proximal to the medial malleolus (middle site, L2), and the medial aspect of the calf between the medial malleolus and the knee (upper site, L3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline subepidermal low echogenic band (SLEB) measurements were 2.46\u00a0\u00b1\u00a00.69\u00a0mm, 2.94\u00a0\u00b1\u00a00.65\u00a0mm, and 2.66\u00a0\u00b1\u00a00.64\u00a0mm at L1, L2, and L3, respectively. There was a significant reduction in SLEB measurement after compression therapy ( p values 0.008, 0.002, and 0.003 at L1, L2, and L3, respectively). The mean percentage reduction in SLEB at level of medial malleolus (mid level \u2010 29.61\u00a0\u00b1\u00a012.24) was higher than the other 2 sites (L1\u201022.45\u00a0\u00b1\u00a015.83 and L3 were 27.57\u00a0\u00b1\u00a012.34).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cutaneous ultrasound aids in accurate assessment of level and severity of edema. Hence, it can be utilized in trials to objectively assess the adequacy of treatment for patients with venous insufficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13040","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T11:20:34Z","timestamp":1616671234000},"page":"904-908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Utility of high\u2010frequency ultrasound in assessing cutaneous edema in venous ulcer patients"],"prefix":"10.1111","volume":"27","author":[{"given":"Shakthi","family":"Pragasam","sequence":"first","affiliation":[{"name":"Department of Dermatology and STD JIPMER Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-9904","authenticated-orcid":false,"given":"Rashmi","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Dermatology and STD JIPMER Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malathi","family":"Munisamy","sequence":"additional","affiliation":[{"name":"Department of Dermatology and STD JIPMER Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devinder","family":"Mohan Thappa","sequence":"additional","affiliation":[{"name":"Department of Dermatology and STD JIPMER Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"126","article-title":"Principles of dermatologic ultrasound diagnostics","volume":"16","author":"Zmudzinska M","year":"2008","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_8_3_1","first-page":"237","article-title":"Application of high frequency ultrasound in dermatology","volume":"26","author":"Bhatta AK","year":"2018","journal-title":"Discov Med"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.20.e126"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000211295"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.98096"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2009.819"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000164199.72440.08"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2004.13.4.26601"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02218.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70271-3"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.13040","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T22:41:10Z","timestamp":1693348870000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,25]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/srt.13040"],"URL":"https:\/\/doi.org\/10.1111\/srt.13040","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"type":"print","value":"0909-752X"},{"type":"electronic","value":"1600-0846"}],"subject":[],"published":{"date-parts":[[2021,3,25]]},"assertion":[{"value":"2020-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}