{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:18:17Z","timestamp":1779214697086,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin microvasculature changes are crucial in psoriasis development and correlate with perfusion. The noninvasive Handheld Perfusion Imager (HAPI) examines microvascular skin perfusion in large body areas using laser speckle contrast imaging (LSCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To (i) assess whether increased perilesional perfusion and perfusion inhomogeneity are predictors for expansion of psoriasis lesions and (ii) assess feasibility of the HAPI system in a mounted modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this interventional pilot study in adults with unstable plaque psoriasis, HAPI measurements and color photographs were performed for lesions present on one body region at week 0, 2, 4, 6 and 8. The presence of increased perilesional perfusion and perfusion inhomogeneity was determined. Clinical outcome was categorized as increased, stable or decreased lesion surface between visits. Patient feedback was collected on a 10\u2010point scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 110 lesions with a median follow\u2010up of 6 (IQR 6.0) weeks were assessed in 6 patients with unstable plaque psoriasis. Perfusion data was matched to 281 clinical outcomes after two weeks. A mixed multinomial logistic regression model revealed a predictive value of perilesional increased perfusion (OR 9.90; p\u00a0&lt;\u00a00.001) and perfusion inhomogeneity (OR 2.39; p\u00a0=\u00a00.027) on lesion expansion after two weeks compared to lesion stability. HAPI measurements were considered fast, patient\u2010friendly and important by patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Visualization of increased perilesional perfusion and perfusion inhomogeneity by noninvasive whole field LSCI holds potential for prediction of psoriatic lesion expansion. Furthermore, the HAPI is a feasible and patient\u2010friendly tool.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13098","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T19:39:31Z","timestamp":1633808371000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Perfusion measured by laser speckle contrast imaging as a predictor for expansion of psoriasis lesions"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7887-6737","authenticated-orcid":false,"given":"Mirjam J.","family":"Schaap","sequence":"first","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7679-7077","authenticated-orcid":false,"given":"Ata","family":"Chizari","sequence":"additional","affiliation":[{"name":"Biomedical Photonic Imaging Technical Medical Centre Faculty of Science and Technology University of Twente Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Knop","sequence":"additional","affiliation":[{"name":"Biomedical Photonic Imaging Technical Medical Centre Faculty of Science and Technology University of Twente Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans M. M.","family":"Groenewoud","sequence":"additional","affiliation":[{"name":"Department for Health Evidence Radboud University Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet E. J.","family":"van Erp","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke M. G. J.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiendelt","family":"Steenbergen","sequence":"additional","affiliation":[{"name":"Biomedical Photonic Imaging Technical Medical Centre Faculty of Science and Technology University of Twente Enschede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke M. B.","family":"Seyger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2009.00669.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.03.023"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"Ec23","article-title":"Expression of Angiogenic Factors in Psoriasis Vulgaris","volume":"11","author":"Sankar L","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200219666180416162942"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_147_17"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08582.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12696791"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1966.16"},{"issue":"3","key":"e_1_2_8_12_1","article-title":"VEGF involvement in psoriasis","volume":"88","author":"Marina ME","year":"2015","journal-title":"Clujul Med"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04287.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.777382"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381628"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12198"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1087-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/35\/7\/R91"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.10.101511"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22788"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20977"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.038"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15339"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12259086"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12522836"},{"issue":"4","key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2340\/0001555564331334","article-title":"Skin blood flow in psoriasis during Goeckerman or beech tar therapy","volume":"64","author":"Staberg B","year":"1984","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1987.tb04116.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00638.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06479.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-96218-6"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.13098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T17:47:01Z","timestamp":1699638421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,7]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/srt.13098"],"URL":"https:\/\/doi.org\/10.1111\/srt.13098","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,7]]},"assertion":[{"value":"2021-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}