{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:12:33Z","timestamp":1772165553136,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Diseased skin in localized scleroderma (LS) and plaque psoriasis (PPs) is characterized by induration that can be evaluated by non\u2010invasive bioengineering methods. In this study, we applied a new measurement device based on indentometry to determine the changes of skin mechanical properties in patients with LS and PPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A total of 30 sclerodermatous plaques in 12 patients with LS and 46 psoriatic plaques in 19 patients with PPs were measured with Indentometer IDM 800 (Courage + Khazaka, Cologne, Germany). The device measures the penetration depth of the probe indenter (pin) into the skin in mm. We used two probes with pin diameters 3 and 5\u00a0mm, respectively. The stiffer the skin, the less deep is the displacement by the indenter. The smaller the diameter, the deeper the pin will go into the skin when using the same force. The measurements were made on diseased skin and in adjacent normal skin served as control.\u00a0In addition, the psoriatic plaques were measured before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sclerodermatous skin and the psoriatic skin showed lower Indentometer values compared to adjacent normal skin as measured with both probes. This suggests that diseased skin is stiffer than healthy skin. The values of psoriatic plaques increased after treatment applied that correlates with the clinical improvement. The Indentometric readings significantly negatively correlated with clinical scores of skin induration. There was a significant correlation between the measurements with probe 3\u00a0mm and probe 5\u00a0mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The non\u2010invasive method used is appropriate for objective and quantitative determination of the degree of skin induration in LS and PPs as well as for assessment of the disease evaluation and treatment efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13134","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T19:23:33Z","timestamp":1642015413000},"page":"317-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of a novel Indentometer to evaluate skin induration in localized scleroderma and psoriasis vulgaris"],"prefix":"10.1111","volume":"28","author":[{"given":"Zlatina","family":"Ivanova","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Medical Faculty Medical University of Plovdiv  Plovdiv Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodor","family":"Aleksiev","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical Faculty Medical University of Plovdiv  Plovdiv Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5513-3789","authenticated-orcid":false,"given":"Hristo","family":"Dobrev","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical Faculty Medical University of Plovdiv  Plovdiv Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolay","family":"Atanasov","sequence":"additional","affiliation":[{"name":"Department of Health Management and Health Economics Faculty of Public Health Medical University of Plovdiv  Plovdiv 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