{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:16:59Z","timestamp":1777893419957,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this pilot study was to provide information about the washout\u2010dependent depletion of important skin components in the horny layer of the scalp. They were taken as markers for scalp drying effects of cosmetic cleansing products and were measured directly in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In vivo confocal Raman spectroscopy was used to measure the depletion of the total natural moisturizing factor (total NMF) and some of its components (urea and lactic acid) as well as a fraction of stratum corneum lipids, after repeated washing with a standard shampoo on the human scalp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The measurements showed a reduction in the amount of NMF and lipids of the stratum corneum caused by repeated shampooing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Confocal Raman spectroscopy is an innovative technology that can be used successfully in vivo on the hairy scalp. The loss of the most important skin components caused by hair washing can be quantified directly with this technology. The method is valuable to support the development cosmetic cleansing products, as it is suitable to directly compare the effects of different product candidates on the human scalp in a most realistic way.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13157","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T09:13:07Z","timestamp":1653988387000},"page":"577-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Confocal Raman spectroscopy is suitable to assess hair cleansing\u2010derived skin dryness on human scalp"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3927-8435","authenticated-orcid":false,"given":"Ghaith","family":"Kourbaj","sequence":"first","affiliation":[{"name":"proderm GmbH  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3230-8558","authenticated-orcid":false,"given":"Stephan","family":"Bielfeldt","sequence":"additional","affiliation":[{"name":"proderm GmbH  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iryna","family":"Kruse","sequence":"additional","affiliation":[{"name":"proderm GmbH  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3262-0557","authenticated-orcid":false,"given":"Klaus\u2010Peter","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"proderm GmbH  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1983.12"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2004.04S1001.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7985-1739-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-79303-8"},{"issue":"1","key":"e_1_2_8_6_1","first-page":"23","article-title":"Natural moisturizing factors (NMF) in the stratum corneum (SC). 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Regeneration of NMF over time after soaking","volume":"61","author":"Robinson M","year":"2010","journal-title":"J Cosmet Sci"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5128376"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050453"},{"key":"e_1_2_8_9_1","first-page":"203","volume-title":"Effects of Natural Moisturizing Factor and Lactic Acid Isomers on Skin Function, in Dry Skin and Moisturizers","author":"Harding C","year":"2005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00774.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01258.x"},{"key":"e_1_2_8_12_1","unstructured":"CaspersP.In vivo skin characterization by confocal Raman microspectroscopy.Thesis Erasmus Universiteit Rotterdam 2003."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-010-2901-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4555(200008\/09)31:8\/9<813::AID-JRS573>3.0.CO;2-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(03)74501-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4322\/rbeb.2014.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00424272"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12365467"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441540"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12289"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1366\/12-06640"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12132"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.13157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T23:54:35Z","timestamp":1692834875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,31]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/srt.13157"],"URL":"https:\/\/doi.org\/10.1111\/srt.13157","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,31]]},"assertion":[{"value":"2021-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}