{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:53:38Z","timestamp":1792007618990,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne treatment may fail or cause undesirable side effects due to inaccurate evaluation. High\u2010frequency ultrasound (HFUS) can monitor systemic treatment in patients with moderate\u2010to\u2010severe acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In this prospective study, consecutive patients with moderate\u2010to\u2010severe acne vulgaris were recruited. Patients were graded by a comprehensive clinical assessment before and after therapy. Simultaneous HFUS grading was independently evaluated according to the sonographic scoring system for acne (SSSA). Clinical and HFUS grades were compared through kappa analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 70 patients were enrolled. At baseline, 36 (51.4%) and 34 (48.6%) patients were graded as moderate and severe, respectively, through clinical assessment. However, 27 patients (38.6%) scored SSSA\u2010Grade II and 43 (61.4%) scored SSSA\u2010Grade III in the HFUS grading. Sixty\u2010one patients (87.1%) were in the consistent category as per clinical assessment and HFUS grades, with Kappa<jats:sub>1<\/jats:sub>\u00a0=\u00a00.745, whereas higher HFUS grades were observed in nine patients. By the end of the observation, 65 of all patients (92.9%) showed significant improvement and 5 (7.1%) showed no apparent improvement after the treatment. According to the clinical assessment, 14, 52, and 4 patients were graded as mild, moderate, and severe, respectively. On the other hand, 11, 51, and 8 patients had SSSA\u2010Grade I, II, and III, respectively. Of all patients, 63 (90.0%) had consistent evaluation results, with Kappa<jats:sub>2<\/jats:sub>\u00a0=\u00a00.762, whereas the remaining seven patients had an HFUS grade higher than the clinical.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HFUS is a useful tool for dermatologists to monitor the treatment of moderate and severe acne vulgaris.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13208","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T11:19:25Z","timestamp":1666696765000},"page":"833-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Value of high\u2010frequency ultrasound in the treatment of moderate and severe acne vulgaris"],"prefix":"10.1111","volume":"28","author":[{"given":"Yanwen","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0972-9511","authenticated-orcid":false,"given":"Juncheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Hospital  Beijing 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