{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:02:53Z","timestamp":1788998573356,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reflectance confocal microscopy (RCM) and line\u2010field confocal optical coherence tomography (LC\u2010OCT) are non\u2010invasive imaging devices that can help in the clinical diagnosis of actinic keratosis (AK) and cutaneous squamous cell carcinoma (SCC). No studies are available on the comparison between these two technologies for the identification of the different features of keratinocyte skin tumours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare RCM and LC\u2010OCT findings in AK and SCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective multicenter study was conducted. Tumours were imaged with RCM and LC\u2010OCT devices before surgery, and the diagnosis was confirmed by histological examinations. LC\u2010OCT and RCM criteria for AK\/SCC were identified, and their presence\/absence was evaluated in all study lesions. Gwet AC1 concordance index was calculated to compare RCM and LC\u2010OCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 52 patients with 33 AKs and 19 SCCs. Irregular epidermis was visible in most tumours and with a good degree of agreement between RCM and LC\u2010OCT (Gwet's AC1 0.74). Parakeratosis, dyskeratotic keratinocytes and both linear dilated and glomerular vessels were better visible at LC\u2010OCT than RCM (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Erosion\/ulceration was identified with both methods in more than half of the cases with a good degree of agreement (Gwet AC1 0.62).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that both LC\u2010OCT and hand\u2010held RCM can help clinicians in the identification of AK and SCC, providing an in vivo and non\u2010invasive identification of an irregular epidermis. LC\u2010OCT proved to be more effective in identifying parakeratosis, dyskeratotic keratinocytes and vessels in this series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13215","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T01:41:20Z","timestamp":1669340480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Comparison of reflectance confocal microscopy and line\u2010field optical coherence tomography for the identification of keratinocyte skin tumours"],"prefix":"10.1111","volume":"29","author":[{"given":"Elisa","family":"Cinotti","sequence":"first","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences Universit\u00e0 degli Studi di Siena  Siena Italy"},{"name":"Groupe d'Imagerie non invasive de la Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-1519","authenticated-orcid":false,"given":"Martina","family":"Bertello","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences Universit\u00e0 degli Studi di Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Cartocci","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-5939","authenticated-orcid":false,"given":"Diletta","family":"Fiorani","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences Universit\u00e0 degli Studi di Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Tognetti","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences Universit\u00e0 degli Studi di Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Solmi","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences Universit\u00e0 degli Studi di Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9813-2391","authenticated-orcid":false,"given":"Simone","family":"Cappilli","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medicine and Traslational Surgery Catholic University of Sacred Heart  Rome Italy"},{"name":"Dermatology Unit, Department of Medical and Surgical Sciences A. Gemelli University Hospital Foundation \u2013 IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketty","family":"Peris","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medicine and Traslational Surgery Catholic University of Sacred Heart  Rome Italy"},{"name":"Dermatology Unit, Department of Medical and Surgical Sciences A. Gemelli University Hospital Foundation \u2013 IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Luc","family":"Perrot","sequence":"additional","affiliation":[{"name":"Groupe d'Imagerie non invasive de la Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie  Paris France"},{"name":"Department of Dermatology University Hospital of Saint\u2010Etienne  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Suppa","sequence":"additional","affiliation":[{"name":"Groupe d'Imagerie non invasive de la Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie  Paris France"},{"name":"Department of Dermatology, H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Department of Dermatology, Institut Jules Bordet Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Del Marmol","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences Universit\u00e0 degli Studi di Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200927060-00002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082956"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366539"},{"key":"e_1_2_8_5_1","article-title":"Diagnostic accuracy of dermoscopy of actinic keratosis: a systematic review","volume":"10","author":"Vald\u00e9s\u2010Morales KL","year":"2020","journal-title":"Dermatol Pract Concept"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14801"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.23.10.106007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14791"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14463"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14716"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12889"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12806"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14581"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.12.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17548"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.34117.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17603"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.13215","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T15:21:55Z","timestamp":1692544915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/srt.13215"],"URL":"https:\/\/doi.org\/10.1111\/srt.13215","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]},"assertion":[{"value":"2022-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13215"}}