{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:48:27Z","timestamp":1782769707793,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiofrequency (RF) devices have been used for skin rejuvenation and treating skin laxity. It may also be effective for senile purpura (SP) based on its action of promoting neocollagenesis with minimal epidermal damage. This study aimed to evaluate the efficacy and safety of microneedle RF for treating SP of the forearms in elderly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In this prospective study, 23 patients who underwent a single session of microneedle RF device (GENIUS, Lutronic Co., Korea) therapy for SP were enrolled. Histopathological features were assessed 1 week before and 8 weeks after therapy. The total amount of collagen and elastic fibers were measured using the computer vision method, and epidermal thickness and the number of blood vessels were analyzed using ImageJ. The clinical improvements were evaluated by blinded evaluators and the patients using investigator global assessment (IGA) and patient global assessment (PGA), respectively. Data regarding the number of purpuric lesions and the size of the largest lesion were collected via a telephone survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total amount of collagen and elastic fibers, and mean epidermal thickness tended to improve after RF treatments, although they did not reach statistical significance. The locally estimated scatterplot smoothing curve showed decreasing tendency in both size and number of purpuras as weeks progressed. PGA showed <jats:italic>very satisfied<\/jats:italic> in 65% of patients and IGA showed 39% near\u2010total improvement and 43% marked improvement. There were no serious adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Microneedle RF therapy induces remodeling of dermal circumstances with minimal epidermal impairment. It may be a promising therapeutic option for SP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13225","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T09:50:03Z","timestamp":1667209803000},"page":"856-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of microneedle radiofrequency therapy in the treatment of senile purpura: A prospective study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7233-1111","authenticated-orcid":false,"given":"Gayun","family":"Baek","sequence":"first","affiliation":[{"name":"Department of Dermatology Veterans Health Service Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Electrical and Electronic Engineering Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihn\u2010Sook","family":"Jue","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hanyang University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13304"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.05.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2019.09.013"},{"key":"e_1_2_9_5_1","volume-title":"Transfusion Medicine and Hemostasis; Clinical and Laboratory Aspects","author":"Shaz BH","year":"2018"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2019.04.006"},{"issue":"4","key":"e_1_2_9_7_1","first-page":"355","article-title":"Treatment of actinic purpura with calcium hydroxyapatite","volume":"10","author":"Souza GP","year":"2018","journal-title":"Surg Cosmet Dermatol (Rio de Janeiro)"},{"issue":"1","key":"e_1_2_9_8_1","first-page":"13","article-title":"Chronic skin fragility of aging: current concepts in the pathogenesis, recognition, and management of dermatoporosis","volume":"11","author":"Dyer JM","year":"2018","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.8.4279"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.11.1326"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13449"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.045"},{"issue":"7","key":"e_1_2_9_13_1","first-page":"756","article-title":"Treatment of skin laxity using multisource, phase\u2010controlled radiofrequency in Asians: visualized 3\u2010dimensional skin tightening results and increase in elastin density shown through histologic investigation","volume":"40","author":"Tanaka Y","year":"2014","journal-title":"Dermatol Surg"},{"key":"e_1_2_9_14_1","volume-title":"StatPearls","author":"Hafsi W","year":"2022"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22071"},{"issue":"3","key":"e_1_2_9_16_1","first-page":"259","article-title":"Skin rejuvenation and wrinkle reduction using a fractional radiofrequency system","volume":"8","author":"Hruza G","year":"2009","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02134.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2019.03.002"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-872410"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001784"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23358"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20731"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1997.tb00677.x"},{"key":"e_1_2_9_24_1","volume-title":"Weedon's Skin Pathology","author":"Patterson JW","year":"2021"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/der2.10"},{"key":"e_1_2_9_26_1","volume-title":"Statistical Models in","author":"Cleveland WS","year":"1992"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.11.1437"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-906-0:219"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdds.2014.05.003"},{"issue":"2","key":"e_1_2_9_30_1","first-page":"135","article-title":"Complications in laser dermatologic surgery. 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