{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:46:38Z","timestamp":1788799598789,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013153","name":"Shantou Science and Technology Project","doi-asserted-by":"publisher","award":["200622175261048"],"award-info":[{"award-number":["200622175261048"]}],"id":[{"id":"10.13039\/501100013153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne is the eighth\u2010most prevalent inflammatory skin disease with no optimal treatment. Photodynamic therapy (PDT) is an effective treatment for severe acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The effect of PDT on the composition and diversity of skin microflora in severe acne patients was studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 18 patients with severe acne and 8 healthy individuals were selected for this study. Patients were treated with 5\u2010aminolevulinic acid\u2010mediated PDT once a week three times in total; the skin microbiome was measured by 16S ribosomal RNA gene sequencing before and after treatment (1 week after each PDT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The microflora composition was different between healthy controls and patients, and between patients before and after treatment. Alpha diversity indices were lower in patients than those in control. There were 15 bacterial genera with high relative abundance that had noticeable changes during treatment. At the genus level,particularly <jats:italic>Cutibacterium acnes<\/jats:italic> (<jats:italic>C. acnes<\/jats:italic> formerly <jats:italic>Propionibacterium acnes<\/jats:italic>), there was no statistically significant difference among different group. The abundances of <jats:italic>Staphylococcus epidermidis<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic> were low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The microbial composition is different between severe acne patients acne patients and healthy individuals. The therapeutic efficacy of severe acne treated with PDT is associated with the composition and diversity of skin microbiota.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The skin microbial composition changes after PDT treatment. PDT is an effective method for the treatment of severe acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13269","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T06:05:27Z","timestamp":1672380327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Photodynamic therapy treats acne by altering the composition of the skin microbiota"],"prefix":"10.1111","volume":"29","author":[{"given":"Yangmin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Dermatology First Affiliated Hospital of Shantou University Medical College  Shantou China"},{"name":"Department of Dermatology Huizhou Dermatology Hospital  Huizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Genetics Shantou University Medical College  Shantou 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