{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:55:43Z","timestamp":1785761743553,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Laser technology has been widely used in the treatment of hypertrophic scar (HPS). Due to the lack of effective quantitative relationship between laser doses and thermal effect of lesion tissue, the selection of laser doses in clinical laser treatment of HPS is blind, which cannot guarantee the best treatment effect.<\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n The photothermal model of HPS was established by using finite element method. The effects of laser dose parameters such as laser energy density, pulse width, and spot diameter on the thermal effects of laser treatment were analyzed. According to tissue temperature threshold and thermal damage degree of the simulation results, the optimal laser doses of HPS were selected for the laser treatment experiments of rabbit ear HPSs to verify the rationality of the quantitative photothermal model.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The temperature rise and thermal damage degree of HPS following laser treatment were directly correlated to the laser doses, which grew with the increase of energy density and laser pulse width. For the different spot diameters, the temperature rise decreased with the increase of spot diameter, whereas the thermal damage degree worsened with the increase of spot diameter. Both simulation and experimental results show that the optimal treatment parameters of HPS were as follows: The laser energy density was 7.5\u00a0J\/cm\n 3<\/jats:sup>\n , the pulse width was 4\u00a0ms, and the spot diameter was 7\u00a0mm.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The laser dose parameters optimized by the photothermal model have achieved good therapeutic effects in the rabbit ear HPS, indicating that the model can be used for quantitative evaluation of laser doses before clinical treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/srt.13305","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:36:29Z","timestamp":1678754189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Quantitative simulation of photothermal effect in laser therapy of hypertrophic scar"],"prefix":"10.1111","volume":"29","author":[{"given":"Jin Cui","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Dermatology Chengdu Second People's Hospital Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya Ya","family":"Liang","sequence":"additional","affiliation":[{"name":"Tribology Research Institute Key Laboratory for Advanced Technology of Materials of Ministry of Education Southwest Jiaotong University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Tribology Research Institute Key Laboratory for Advanced Technology of Materials of Ministry of Education Southwest Jiaotong University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12627386"},{"issue":"5","key":"e_1_2_9_3_1","first-page":"276","article-title":"Establishment and application of experimental animal model for hypertrophic scar","volume":"17","author":"Li H","year":"2001","journal-title":"Chin J Plast Surg"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2021.110783"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836297"},{"key":"e_1_2_9_6_1","first-page":"4","article-title":"Nd:YAG laser treatment of keloids and hypertrophic scars","volume":"12","author":"Akaishi S","year":"2012","journal-title":"Eplasty"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.4.448"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamadermatol.668"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"216","article-title":"Laser\u2010tissue interactions: fundamentals and applications","volume":"36","author":"Niemz MH","year":"2007","journal-title":"Med Phys"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02133614"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-006-0427-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3788\/AOS20082805.0943"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.7.077005"},{"issue":"3","key":"e_1_2_9_14_1","first-page":"354","article-title":"Analysis of skin, muscle and brachial arterial blood temperatures in the resting normal human forearm","volume":"215","author":"Pennes HH","year":"1948","journal-title":"Am J Med Sci"},{"issue":"4","key":"e_1_2_9_15_1","first-page":"530","article-title":"Studies of thermal injury: I. The conduction of heat to and through skin and the temperatures attained therein. A theoretical and an experimental investigation","volume":"23","author":"Henriques FC","year":"1947","journal-title":"Am J Pathol"},{"key":"e_1_2_9_16_1","volume-title":"Observation of hypertrophic scar and keloid with color doppler ultrasound","author":"Li B","year":"2005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.11.052"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31820d15f0"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.13305","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:54:04Z","timestamp":1773014044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/srt.13305"],"URL":"https:\/\/doi.org\/10.1111\/srt.13305","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"2022-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13305"}}