{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T02:16:26Z","timestamp":1772244986488,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173449"],"award-info":[{"award-number":["82173449"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232114"],"award-info":[{"award-number":["7232114"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although the cutaneous involvement of acromegaly has been recognized, the submacroscopical skin changes and the extent of skin thickening of patients remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed at investigating the clinical cutaneous manifestations, dermoscopic features, and skin thickness revealed by high\u2010frequency ultrasound (HFUS) of acromegalic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case\u2010control observational study was conducted. Patients with acromegaly and controls were prospectively included and received thorough cutaneous examinations to compare the macroscopical and dermoscopic features. The skin thickness measured by HFUS and its correlation with clinical data were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010seven and 26 patients from acromegalic and control group were included, respectively. Clinical skin manifestations were recorded in detail. Under dermoscopy, red structureless area (91.9%\u00a0vs. 65.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.021), perifollicular orange halo (78.4%\u00a0vs. 26.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005), and follicular plug (70.3%\u00a0vs. 3.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) in the facial area, and perifollicular pigmentation (91.9%\u00a0vs. 23.1%), broom\u2010head hairs (83.8%\u00a0vs. 3.9%), honeycomb\u2010like pigmentation (97.3%\u00a0vs. 38.46%), widened dermatoglyphics (81.1%\u00a0vs. 3.9%) at the extremities (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) were more prevalent in acromegaly. The mean skin thickness was 4.10\u00a0\u00b1\u00a00.48\u00a0mm for acromegaly, and 3.55\u00a0\u00b1\u00a00.52\u00a0mm for controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) but no correlation with disease duration, adenoma size, and hormone level was found in acromegaly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Submacroscopical skin changes under dermoscopy and skin thickness increase assessed by HFUS can provide clinicians with subtle evidences for early detection of acromegaly and objective parameters for accurate assessment of its skin involvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13319","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:53:53Z","timestamp":1682038433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Skin manifestations and submacroscopical features of acromegaly: A case\u2010control study using dermoscopy and high\u2010frequency ultrasound"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-9379","authenticated-orcid":false,"given":"Yukun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"China Pituitary Disease Registry Center  Beijing China"},{"name":"China Pituitary Adenoma Specialist Council  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-2429","authenticated-orcid":false,"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"China Pituitary Disease Registry Center  Beijing China"},{"name":"China Pituitary Adenoma Specialist Council  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010019\u20100071\u20106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/573643"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2018.04.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4125013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2102616"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010017\u20101511\u20102"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00722"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00492"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010016\u20109378\u20108"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.2009.03626.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/erc\u201017\u20100253"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.072"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010016\u20100141\u20106"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13089\u2010021\u201000222\u2010w"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450147"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.04.011"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10765"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014\u20102700"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19699"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.229"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1982.00340230060013"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2012.02.006"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102265.2000.01141.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1566\u20100702(01)00257\u20100"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413205"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.47.supplmarch_s41"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16312"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12407"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12146"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.1983.tb00578.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102\u2010020\u201001037\u2010z"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T11:38:42Z","timestamp":1764502722000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/srt.13319"],"URL":"https:\/\/doi.org\/10.1111\/srt.13319","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"2023-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13319"}}