{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:45:21Z","timestamp":1791938721449,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T00:00:00Z","timestamp":1682121600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgrounds<\/jats:title>\n                    <jats:p>\n                      Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit affecting most teenagers and numerous adults throughout the world. The present study was designed to assess the association of the presence or absence of\n                      <jats:italic>GSTM1<\/jats:italic>\n                      ,\n                      <jats:italic>GSTT1<\/jats:italic>\n                      , and single nucleotide polymorphisms rs1695 in\n                      <jats:italic>GSTP1<\/jats:italic>\n                      and rs1042522 in\n                      <jats:italic>TP53<\/jats:italic>\n                      gene with acne vulgaris.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The cross\u2010sectional case\u2013control study was conducted at the Institute of Zoology from May 2020 to March 2021 and included acne vulgaris patients (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0100) and controls (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0100) enrolled in Dera Ghazi Khan district, Pakistan. Multiplex and tetra\u2010primer amplification refractory mutation system\u2010polymerase chain reactions were applied to investigate the genotype in analyzed genes. The association of rs1695 and rs1042522 with acne vulgaris was studied either individually or in various combinations with\n                      <jats:italic>GATM1<\/jats:italic>\n                      and\n                      <jats:italic>T1<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant association of absence of\n                      <jats:italic>GSTT1<\/jats:italic>\n                      and mutant genotype at rs1695 (GG) and at rs1042522 (CC) in\n                      <jats:italic>GSTP1<\/jats:italic>\n                      and\n                      <jats:italic>TP53<\/jats:italic>\n                      , respectively, was found to be associated with acne vulgaris in enrolled subjects. Subjects aged 10\u201325 years and smokers were more susceptible to acne vulgaris.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our results suggest that genotypes of glutathione S\u2010transferases (GSTs) and\n                      <jats:italic>TP53<\/jats:italic>\n                      are involved in protection against oxidative stress and may influence disease progression in acne vulgaris.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13333","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T06:25:14Z","timestamp":1682144714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Absence of\n                    <i>GSTT1<\/i>\n                    and polymorphisms in\n                    <i>GSTP1<\/i>\n                    and\n                    <i>TP53<\/i>\n                    are associated with the incidence of acne vulgaris"],"prefix":"10.1111","volume":"29","author":[{"given":"Rehmat","family":"Ullah","sequence":"first","affiliation":[{"name":"Institute of Zoology Bahauddin Zakariya University  Multan Pakistan"},{"name":"Department of Biology Virtual University of Pakistan  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sher","family":"Afgan","sequence":"additional","affiliation":[{"name":"Department of Zoology Ghazi University  Dera Ghazi Khan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariyam","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Institute of Zoology Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Asif","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Latif","sequence":"additional","affiliation":[{"name":"Department of Zoology, Division of Science and Technology University of Education  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashid","family":"Mehmood","sequence":"additional","affiliation":[{"name":"Institute of Zoology Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Naeem","sequence":"additional","affiliation":[{"name":"Institute of Zoology Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Zahra","sequence":"additional","affiliation":[{"name":"Institute of Zoology Bahauddin Zakariya University  Multan Pakistan"},{"name":"Department of Internal Medicine Division of Oncology Washington 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