{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:03Z","timestamp":1775520003216,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Psoriasis is a chronic, complicated, and recurrent inflammatory skin disease, whose precise molecular mechanisms need to be further explored. The lncRNA bladder cancer\u2010associated transcript 1 (\n                      <jats:italic>BLACAT1<\/jats:italic>\n                      ) is aberrantly expressed in many cancers and associated with cellular hyperproliferation and may play a role in the pathogenesis of psoriasis. Thus, this study aimed at identifying the primary mechanism associated with\n                      <jats:italic>BLACAT1<\/jats:italic>\n                      in psoriasis pathogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Quantitative reverse transcriptase polymerase chain reaction (qRT\u2010PCR) was performed to detect the expression of\n                      <jats:italic>BLACAT1<\/jats:italic>\n                      in psoriasis tissues. Cell proliferation and apoptosis were assessed using cell counting kit\u20108 and apoptosis assays, respectively. In vivo experiments and histopathological examinations were performed to investigate the effects of\n                      <jats:italic>BLACAT1<\/jats:italic>\n                      on psoriasis. Dual\u2010luciferase Reporter and RNA immunoprecipitation assays were used to evaluate the relationship among\n                      <jats:italic>BLACAT1<\/jats:italic>\n                      and\n                      <jats:italic>miR\u2010149\u20105p<\/jats:italic>\n                      and\n                      <jats:italic>AKT1<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>BLACAT1<\/jats:italic>\n                      was upregulated in psoriasis tissues. Overexpression exacerbated the clinical manifestation of psoriasis and increased the epidermal thickness in imiquimod\u2010induced mice.\n                      <jats:italic>BLACAT1<\/jats:italic>\n                      could promote proliferation and inhibit apoptosis of keratinocytes. Further studies demonstrated that\n                      <jats:italic>BLACAT1<\/jats:italic>\n                      positively regulated\n                      <jats:italic>AKT1<\/jats:italic>\n                      expression, functioning as a competing endogenous RNA (ceRNA) by sponging\n                      <jats:italic>miR\u2010149\u20105p<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The combination of lncRNA\n                      <jats:italic>BLACAT1<\/jats:italic>\n                      and\n                      <jats:italic>miR\u2010149\u20105p<\/jats:italic>\n                      regulates\n                      <jats:italic>AKT1<\/jats:italic>\n                      expression and promotes psoriasis formation thus may provide a new direction for psoriasis treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13339","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T22:36:01Z","timestamp":1683758161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["RETRACTED: Pathogenesis of psoriasis via miR\u2010149\u20105p\/AKT1axis by long noncoding RNA BLACAT1"],"prefix":"10.1111","volume":"29","author":[{"given":"Xiang","family":"Hua","sequence":"first","affiliation":[{"name":"Department of Dermatology Nanfang Hospital of Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiaZheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital of Southern Medical University Guangzhou China"},{"name":"Department of Dermatology Guangzhou Panyu central hospital Guangzhou 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