{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:07Z","timestamp":1773705607388,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of secukinumab treatment for psoriasis on different functional cytokines and inflammatory mediators in patients\u2019 serum<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Enzyme\u2010linked immunosorbent assay was used to detect interleukin (IL)\u20101\u03b2 and IL\u20101RA associated with intrinsic immunity; IL\u20106, IL\u201018, and growth regulated oncogene alpha (GRO\u03b1) associated with neutrophils;\u00a0IL\u201012, tumour necrosis factor (TNF)\u2010\u03b1, and interferon (IFN)\u2010\u03b3 associated with Th1; IL\u201023, IL\u201017A, and IL\u201022 associated with Th17; Thymus activation regulated chemokine (TARC), IL\u201013, and defensin beta 2 (DEFB2) associated with Th2; Vascular endothelial growth factor (VEGF)\u2010A and IL\u201010 associated with angiogenesis; and IFN\u2010\u03b3 associated with sepsis in the peripheral blood of 12 patients with common psoriasis treated with secukinumab and 15 healthy controls. IL\u201023, IL\u201017A, IL\u201022 associated with Th17; TARC, IL\u201013, DEFB2 associated with Th2; VEGF\u2010A, IL\u201010 associated with angiogenesis and procalcitonin (PCT) associated with sepsis. The differences in expression of the above cytokines before and after treatment and the correlation with psoriasis disease severity\uff3bPsoriasis Area Severity Index(PASI) score\uff3d, age, and disease duration were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean PASI score of the enrolled patients with moderate to severe psoriasis was 21.6\u00a0\u00b1\u00a011.0 before treatment and decreased to below 1 after treatment. Serum IL\u20106; IL\u201018, GRO\u03b1, IFN\u2010\u03b3, TNF\u2010\u03b1, VEGF\u2010A, and IL\u201017A were significantly higher than normal. And IL\u201017A and IFN\u2010\u03b3 were positively correlated with disease duration and age, and IL\u201018 was positively correlated with PASI score. The expression levels of IL\u20106, GRO\u03b1, VEGF\u2010A, IFN\u2010\u03b3, TNF\u2010\u03b1, IL\u201017A and IL\u201023 were significantly lower after secukinumab treatment compared with those before treatment, but the expression levels of IFN\u2010\u03b3, VEGF\u2010A, TARC, IL\u201013, and DEFB2 were still significantly higher than those of normal subjects after treatment<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>secukinumab clears skin lesions by antagonizing IL\u201017A and simultaneously decreasing the expression levels of IL\u20106, GRO \u03b1, VEGF\u2010A, IFN\u2010\u03b3, TNF\u2010\u03b1, IL\u201017A, and IL\u201023.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13405","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T02:04:46Z","timestamp":1688695486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["RETRACTED: The effect of secukinumab treatment for psoriasis on serum cytokines and correlation with disease severity"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8142-894X","authenticated-orcid":false,"given":"Lan\u2010Tu\u2010Ya","family":"Wu","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science, Health Science Center Shenzhen University Shenzhen China"},{"name":"Department of Dermatology The University of Hong Kong\u2010Shenzhen Hospital Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu\u2010Hui","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Hong 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