{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:25:16Z","timestamp":1788200716589,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Seborrheic keratoses (SK) is a benign epithelial skin tumor and plasma exeresis is a new technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of plasma exeresis and cryotherapy for treating SK.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is a randomized controlled trial (RCT). One side of each patient was randomly treated with plasma exeresis (peak\u2010to\u2010peak voltage of 3.44\u00a0kV and a frequency of 62.5\u00a0kHz) and the other side with cryotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five males were enrolled. At week 3, 37.1 % (N\u00a0=\u00a013) of lesions treated by plasma exeresis were clear, which was higher than those treated by cryotherapy 17.1% (N\u00a0=\u00a06). However, this difference was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value: 0.06). At week 6, 16 (57.1 %) out of 28 remaining lesions, treated by plasma exeresis were clear, which was significantly higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value: 0.005) than those completely cleared by cryotherapy in 6 out of 29 remaining lesions (20.7%).\n                    <\/jats:p>\n                    <jats:p>\n                      The mean physician assessment scale score was significantly reduced in both groups in the second follow\u2010up (plasma group first follow\u2010up 0.91\u00a0\u00b1\u00a00.89\u00a0vs. second follow\u2010up 0.5\u00a0\u00b1\u00a00.64 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value: 0.0031; cryo group first follow\u2010up 1.4\u00a0\u00b1\u00a00.84\u00a0vs. second follow\u2010up 1.1\u00a0\u00b1\u00a00.72 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value: 0.0002).\n                    <\/jats:p>\n                    <jats:p>\n                      Regarding side effects, no significant difference was seen (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.438). The most common complications in the plasma and cryotherapy groups were erythema (10\/19, 52.63%) and hypo pigmentation (5\/13, 38.46%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both cryotherapy and plasma exeresis are effective. We observed a significantly higher cleared lesions treated with plasma exeresis in 6\u00a0weeks and after two sessions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13429","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T01:24:51Z","timestamp":1690507491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial"],"prefix":"10.1111","volume":"29","author":[{"given":"Maryam","family":"Noorbakhsh","sequence":"first","affiliation":[{"name":"Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-4591","authenticated-orcid":false,"given":"Yasamin","family":"Kalantari","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erfan","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Laser and Plasma Research Institute Shahid Beheshti University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Shokri","sequence":"additional","affiliation":[{"name":"Laser and Plasma Research Institute Shahid Beheshti University Tehran Iran"},{"name":"Physics Department of Shahid Beheshti University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1890-1005","authenticated-orcid":false,"given":"Hamidreza","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1020-8895","authenticated-orcid":false,"given":"Maryam","family":"Daneshpazhooh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-2485","authenticated-orcid":false,"given":"Ifa","family":"Etesami","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Khani","sequence":"additional","affiliation":[{"name":"Laser and Plasma Research Institute Shahid Beheshti University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517070"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.18983.1"},{"key":"e_1_2_10_4_1","volume-title":"StatPearls [Internet]","author":"Greco MJ","year":"2022"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"1","article-title":"Topical trichloroacetic acid versus cryotherapy in the treatment of seborrheic keratoses: a prospective comparative study","volume":"32","author":"Kalegowda D","year":"2022","journal-title":"J Pak Assoc Dermatol"},{"issue":"1","key":"e_1_2_10_6_1","first-page":"1","article-title":"Efficacy and safety of topical treatments for seborrheic keratoses: a systematic review","volume":"34","author":"Natarelli N","year":"2022","journal-title":"J Dermatol Treat"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S348106"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2018.460"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104632.2004.02282.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201034425\u2010z"},{"issue":"3","key":"e_1_2_10_11_1","first-page":"E58","article-title":"A Descriptive study on the applications of plasma exeresis in dermatology","volume":"14","author":"Sotiris TG","year":"2021","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_12_1","first-page":"17","article-title":"Applications of plasma exeresis in dermatology","volume":"2","author":"Rossi E","year":"2016","journal-title":"Hi\u2010Tech 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