{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:38:32Z","timestamp":1773815912417,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few studies have examined the effectiveness of the reciprocity law in ultraviolet excimer therapy. This study aimed to examine the difference in erythematous reaction in human skin when the irradiance of ultraviolet excimer treatment devices differed while the irradiation dose was constant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      This study, conducted at the Department of Dermatology, Chiba University, included 15 healthy adults aged 20\u201365 years (mean age, 46.3 years; seven men). Using ultraviolet excimer treatment devices with different irradiances (50 or 150\u00a0mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ), the upper abdomen of each participant was irradiated with ultraviolet light at set irradiation doses (80, 100, 120, 140, 160, 180, and 200 mJ\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ). The erythema index of each irradiated site was measured using a melanin\u2010 and erythema\u2010measuring device, and the difference in erythema index before and 24\u00a0h after irradiation was the primary endpoint.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The change in erythema index was significantly higher for an irradiance of 150\u00a0mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      . Significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) were observed between these irradiance levels at irradiation doses of 100\u2012200 mJ\/cm\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Even for the same irradiation dose, stronger erythematous reactions occurred at higher irradiances in ultraviolet excimer treatment. This suggests that the reciprocity law may not always hold true in excimer therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13437","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T03:35:03Z","timestamp":1691724903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Erythematous reactions to two ultraviolet excimer therapy devices with different irradiance levels: Reconsidering the reciprocity law"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8472-3609","authenticated-orcid":false,"given":"Yaei","family":"Togawa","sequence":"first","affiliation":[{"name":"Department of Dermatology Chiba University Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusuke","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chiba University Graduate School 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