{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:37:05Z","timestamp":1790959025336,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016262","name":"PharmaResearch Products","doi-asserted-by":"publisher","award":["S\u20102023\u20100690\u20100000\u201001"],"award-info":[{"award-number":["S\u20102023\u20100690\u20100000\u201001"]}],"id":[{"id":"10.13039\/501100016262","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polynucleotides (PN) are increasingly used for the treatment of facial erythema in the Republic of Korea. However, there are limited pre\u2010clinical and clinical data on the efficacy of polynucleotides for facial erythema. In this study, we investigated the current practice and perceived effectiveness of polynucleotide treatment for facial erythema among cosmetic physicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>By conducting a survey among clinicians who use PN in clinical practice, we explored the current practices and assessed the perceived effectiveness of polynucleotides in treating facial erythema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 557 physicians who used polynucleotides for facial erythema participated in the survey. Polynucleotides were used by 84.4%, 66.4%, and 47.4% of physicians for facial erythema caused by inflammatory facial dermatosis, repeated laser\/microneedle radiofrequency, and steroid overuse, respectively. Among those users, 88.1%, 90%, and 83.7% respectively in those same categories answered that polynucleotides were \u201chighly effective\u201d or \u201ceffective.\u201d Furthermore, they agreed that polynucleotides have the following properties: wound healing\/regeneration (95.8%), protection of skin barrier (92.2%), hydration (90.5%), vascular stabilization (81.0%), and anti\u2010inflammation (79.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings showed that cosmetic physicians in the Republic of Korea have used PN as a part of combination treatment for facial erythema resulting from inflammatory facial dermatosis and repeated laser\/ microneedle radiofrequency, rather than from steroid overuse. Also, most clinicians agreed that PN was effective for treatment of facial erythema. Given the lack of pre\u2010clinical and clinical trial evidence, the empirical responses of practicing physicians provide useful information to guide clinical practice and further research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13466","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T01:53:24Z","timestamp":1694138004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Current practices and perceived effectiveness of polynucleotides for treatment of facial erythema by cosmetic physicians"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0317-3594","authenticated-orcid":false,"given":"Dagyeong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Family Medicine\/Supportive Care Center Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Aeon Medical and Aesthetic Center  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Maylin Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong Chan","family":"Rah","sequence":"additional","affiliation":[{"name":"Robbin Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosung","family":"Choi","sequence":"additional","affiliation":[{"name":"Piena Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Tae","family":"Anh","sequence":"additional","affiliation":[{"name":"Reyoung Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gun Hyon","family":"Ji","sequence":"additional","affiliation":[{"name":"Yonseidongan Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Seong","family":"Kim","sequence":"additional","affiliation":[{"name":"INEE Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geebum","family":"Kim","sequence":"additional","affiliation":[{"name":"Misogain Dermatology Clinic  Gimpo Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Wook","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Family Medicine\/Supportive Care Center Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Department of Clinical Research Design &amp; Evaluation Samsung Advanced Institute for Health Science &amp; Technology (SAIHST) Sungkyunkwan University  Seoul Republic of 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