{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:08:46Z","timestamp":1791842926778,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periorbital hyperpigmentation (POH) is a common cosmetic concern. Numerous techniques of treatment have been assessed with variable results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this research is to assess the efficacy of non\u2010ablative radiofrequency, Sublative fractional Radiofrequency (SFR) on POH treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this research study, nine patients with POH and the age range of 25\u221257 years, were enrolled. The patients were treated by non\u2010ablative radiofrequency SRF. The outcomes were assessed by biometric assessment. The skin lightness and melanin content of the periorbital skin were assessed by colorimeter and Mexameter. Skin elasticity was assessed by Cutometer. The skin ultrasound imaging system was used to evaluate the diameter and density of the epidermis and dermis. Visioface was used to evaluate the skin color and wrinkles. Also, patient's satisfaction and physician's assessment were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that the lightness and elasticity of the periorbital skin were significantly increased after treatment. Also, the melanin content of the skin was decreased. The denser skin layers were seen in both dermis and epidermis. The Visioface results displayed the reduction in the percent change of the skin color and wrinkle (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Similarly, the physician and patients\u2019 assessment confirmed the outcomes. No serious adverse effect was reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, the SFR technique is an effective and satisfactory therapeutic choice for treatment of POH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13467","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:43:47Z","timestamp":1694583827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of periorbital hyperpigmentation using sublative fractional radiofrequency (SFR)"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6143-8039","authenticated-orcid":false,"given":"Mohammad Ali","family":"Nilforoushzadeh","sequence":"first","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Skin Repair Research Center Jordan Dermatology and Hair Transplantation Center  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Heidari\u2010Kharaji","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Skin Repair Research Center Jordan Dermatology and Hair Transplantation Center  Tehran Iran"},{"name":"Institut National de la Recherche Scientifique (INRS)\u2010Centre Armand\u2010Frappier Sant\u00e9 Biotechnologie (CAFSB)  Laval Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tannaz","family":"Fakhim","sequence":"additional","affiliation":[{"name":"Skin Repair Research Center Jordan Dermatology and Hair Transplantation Center  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3116-3163","authenticated-orcid":false,"given":"Elham","family":"Torkamaniha","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Skin Repair Research Center Jordan Dermatology and Hair Transplantation Center  Tehran Iran"},{"name":"Department of Microbial Biotechnology Islamic Azad University  Kish Branch Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Tehrani","sequence":"additional","affiliation":[{"name":"Department of Dermatology Amir Al Momenin Teaching Hospital  Tehran Iran"},{"name":"Tehran Medical Branch School of Medicine Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohreh","family":"Delavar","sequence":"additional","affiliation":[{"name":"Islamic Azad University of Medical Sciences Shariati St  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohreh","family":"Rafiee","sequence":"additional","affiliation":[{"name":"Skin Repair Research Center Jordan Dermatology and Hair Transplantation Center  Tehran 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