{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:10:55Z","timestamp":1790809855052,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prior observational studies have identified a relationship between the composition of gut microbiota and the onset of acne. To ascertain the causal relationship underlying this association, we adopted the Mendelian randomization (MR) method, which offers a powerful approach to causal inference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Summary statistics on gut microbiota and acne were obtained from the MiBioGen and FinnGen consortium, respectively. The causal relationship was assessed using multiple methods in a two\u2010sample framework, including MR Egger, weighted median, inverse variance weighted (IVW), and weighted mode. Furthermore, the heterogeneity and horizontal pleiotropy analyses were conducted, along with the leave\u2010one\u2010out method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IVW estimation indicated that <jats:italic>Allisonella<\/jats:italic> (odds ratio [OR]\u00a0=\u00a01.42, 95% confidence interval [CI]\u00a0=\u00a01.18\u20131.70, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0002) and <jats:italic>Bacteroides<\/jats:italic> (OR\u00a0=\u00a02.25, 95% CI\u00a0=\u00a01.48\u20133.42, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0001) have adverse effects on acne. By contrast, <jats:italic>Ruminococcus torques<\/jats:italic> group (OR\u00a0=\u00a00.41, 95% CI\u00a0=\u00a00.25\u20130.65, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0002) showed a beneficial effect on acne. In addition, <jats:italic>Candidatus soleaferrea<\/jats:italic> (OR\u00a0=\u00a00.75, 95% CI\u00a0=\u00a00.60\u20130.95, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0149), <jats:italic>Eubacterium coprostanoligenes<\/jats:italic> group (OR\u00a0=\u00a00.67, 95% CI\u00a0=\u00a00.47\u20130.95, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0230), <jats:italic>Fusicatenibacter<\/jats:italic> (OR\u00a0=\u00a00.71, 95% CI\u00a0=\u00a00.52\u20130.97, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02897), and <jats:italic>Lactobacillus<\/jats:italic> (OR\u00a0=\u00a00.72, 95% CI\u00a0=\u00a00.58\u20130.90, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0046) showed suggestive associations with acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present investigation suggests a causal effect of gut microbiota on acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13473","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T01:30:23Z","timestamp":1695087023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Gut microbiota and acne: A Mendelian randomization study"],"prefix":"10.1111","volume":"29","author":[{"given":"Qiurui","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Anorectal Surgery Jiangmen Wuyi Hospital of Traditional Chinese Medicine  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery Jiangmen Wuyi Hospital of Traditional Chinese Medicine  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangqing","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery Jiangmen Wuyi Hospital of Traditional Chinese Medicine  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery Jiangmen Wuyi Hospital of Traditional Chinese Medicine  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Luo","sequence":"additional","affiliation":[{"name":"Clinical Medical College Jiangxi University of Traditional Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.446"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61729-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.012"},{"key":"e_1_2_9_5_1","first-page":"734","article-title":"Diagnosis and treatment of acne","volume":"86","author":"Titus S","year":"2012","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12298"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14385"},{"key":"e_1_2_9_9_1","first-page":"2123","article-title":"Diagnosis and treatment of acne","volume":"69","author":"Feldman S","year":"2004","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304070-00004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2096995"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15951"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14586"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2968"},{"key":"e_1_2_9_15_1","first-page":"39","article-title":"Impact of the impaired intestinal microflora on the course of acne vulgaris","volume":"79","author":"Volkova LA","year":"2001","journal-title":"Klin Med (Mosk)"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7010014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu328"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.737197"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.971376"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02761-6"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-00763-1"},{"key":"e_1_2_9_22_1","article-title":"FinnGen: unique genetic insights from combining isolated population and national health register data","author":"Kurki MI","year":"2022","journal-title":"medRxiv"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0350-x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr036"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21758"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz124"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0099-7"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42113-018-0011-7"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu005"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1530509100"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007081"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1492-2"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14952"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.15698\/mic2016.06.508"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020620607611"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2015.02.001"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041368"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2020.102243"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362491"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800100-4.00003-9"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1895064"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17111870"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-5394-8"},{"key":"e_1_2_9_45_1","first-page":"1","article-title":"Alteration of intestinal microbiota in 3\u2010deoxyglucosone\u2010induced prediabetic rats","volume":"2020","author":"Cai J","year":"2020","journal-title":"BioMed Res Int"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO01490J"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-44-1-137"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b04994"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.700718"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-021-03498-9"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-022-00737-9"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01459"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1016872"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.3.840-846.1995"},{"key":"e_1_2_9_55_1","first-page":"229","article-title":"Medium\u2010chain triglycerides reduce diarrhea with improved immune status and gut microbiomics in tunnel workers in China","volume":"31","author":"Xu Q","year":"2022","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/206731"},{"key":"e_1_2_9_57_1","article-title":"Probiotic species in the modulation of gut microbiota: an overview","volume":"2018","author":"MdAK Azad","year":"2018","journal-title":"BioMed Res Int"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T07:49:29Z","timestamp":1753170569000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":56,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/srt.13473"],"URL":"https:\/\/doi.org\/10.1111\/srt.13473","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"2023-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13473"}}