{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:39:02Z","timestamp":1777945142671,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Insulin resistance (IR) is a condition where cells become resistant to insulin, causing impaired glucose uptake and increased blood glucose levels. Interleukin\u201012 (IL\u201012), a cytokine, regulates the immune system. High levels of IL\u201012 can lead to chronic inflammation, exacerbate resistance to insulin, and contribute to type 2 diabetes. Also, link IR to acne vulgaris (AV), as it reduces tissue sensitivity to insulin, causing increased insulin levels and sebum production, which can contribute to acne development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To explore the role of IL\u201012 gene expression on IR in AV patients and to study the role of IL\u201012 gene in the development of AV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>A case\u2013control study was performed on 68 AV patients and 68 healthy controls. The biochemical analysis included fasting glucose, fasting insulin, (HOMA\u2010IR), and serum IL\u201012 level. IL\u201012 gene expression was performed by quantitative real\u2010time PCR for both two groups. In addition, folding change was calculated by using the standard 2\u2013(\u2206\u2206Ct) method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>IL\u201012 level, IL\u201012 folding change, fasting insulin, and IR were all increased in acne patients. A highly significant linear correlation was found between IL\u201012 folding change and both IL\u201012 levels and IR. There is a substantial positive significant simple linear association between IL\u201012 level and IL\u201012 folding change, as well as IR and IL\u201012 folding change, in moderate and severe acne.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL\u201012 gene has an important role in IR and the development of acne in AV patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13503","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T02:34:12Z","timestamp":1698201252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["RETRACTED: Effect of interleukin\u201012 gene expression on insulin resistance in patients with acne vulgaris"],"prefix":"10.1111","volume":"29","author":[{"given":"Ahmed Ibrahim","family":"AbdElneam","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Department of Basic Medical Sciences, College of Medicine Shaqra University  Dawadmi Saudi Arabia"},{"name":"Molecular Genetics and Enzymology Department, Human Genetics and Genome Research Institute National Research Center  Dokki Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Saleh","family":"Al\u2010Dhubaibi","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, College of Medicine Shaqra University  Dawadmi Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh Salem","family":"Bahaj","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences Sana'a University  Sana\u02bda Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada 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