{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:35:18Z","timestamp":1772688918587,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2020JJ5431"],"award-info":[{"award-number":["2020JJ5431"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rosacea, a common chronic inflammatory skin disease worldwide, is currently incurable with complex pathogenesis. Dendrobium polysaccharide (DOP) may exert therapeutic effects on rosacea via acting on the NF\u2010\u03baB\u2010related inflammatory and oxidative processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In this study, an LL\u201037\u2010induced rosacea\u2010like mouse model was established. HE staining was used to assess the skin lesions, erythema severity scores, pathological symptoms, and inflammatory cell numbers of mice in each group. The inflammation level was quantitatively analyzed using enzyme\u2010linked immunosorbent assay (ELISA) and reverse transcription\u2010quantitative real\u2010time polymerase chain reaction (RT\u2010qPCR). The expression levels of TLR4 and p\u2010NF\u2010\u03baB were finally detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DOP improved skin pathological symptoms of rosacea mice. DOP also alleviated the inflammation of rosacea mice. Moreover, the TLR4\/NF\u2010\u03baB pathway was observed to be inhibited in the skin of mice after DOP application. These findings evidenced the anti\u2010inflammatory effects of DOP on the LL\u201037\u2010induced rosacea mouse model. DOP could inhibit NF\u2010\u03baB activation, suppress neutrophil infiltration, and reduce pro\u2010inflammatory cytokines production, which may be the reason for DOP protecting against rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study may propose an active candidate with great potential for rosacea drug development and lay a solid experimental foundation for promoting DOP application in rosacea therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13543","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T02:25:05Z","timestamp":1704680705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dendrobium polysaccharide (DOP) ameliorates the LL\u201037\u2010induced rosacea by inhibiting NF\u2010\u03baB activation in a mouse 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