{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T20:28:21Z","timestamp":1785184101361,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To summarize and analysis the application of biologic agents in patients with psoriasis in the real world.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Relying on collected data from June 2020 to September 2021 in the database of China Psoriasis Standardized Diagnosis and Treatment Center, 2529 cases of psoriasis patients treated with biologic agents in 188 different tertiary hospitals across China were retrospective analyzed. The collected information mainly includes demographic data (age, gender, psoriasis history), curative effectiveness of used biologics drug withdrawal and its reason. According to the collected information, condition of the usage for each category of biologics and influencing factor of biologics replacement were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>A total of 2529 patients were analyzed, which included 1626 male (64.29%) and 903 female (35.71%) with an average age of 42.12\u00a0\u00b1\u00a014.70 (17\u00a0\u223c\u00a085) years old; 2336 (92.37%) patients were aged from 19 to 60 years old. Within these patients, 2362 of them (93.40%) had a psoriasis area and severity index (PASI) score, and 1776 of these patients had moderate to severe cases (75.19%). According to the patient's self\u2010evaluation of the past efficacy of biological agents, secukinumab was chosen by the most people to have the highest efficacy (1140 cases, 93.60%). The main reason for the withdrawal of secukinumab is that the disease is already well controlled at the time of withdrawal (67 cases, 38.95%); for TNF\u2010 \u03b1 inhibitor is the poor curative effect; for ustekinumab and ixekizumab were the non\u2010affordable price.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the current biotherapy of psoriasis in China, the efficacy of secukinumab is thought by most people to be the highest. Secukinumab is the first choice when the needs of changing biologics appear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13550","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T05:59:01Z","timestamp":1704347941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["RETRACTED: Use of biologics in patients with psoriasis \u2013 A retrospective analysis based on real\u2010world data"],"prefix":"10.1111","volume":"30","author":[{"given":"Jing","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Beijing Jishuitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Dermotologic Diseases and Immunologic Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Beijing Jishuitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Dermotologic Diseases and Immunologic Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Beijing Jishuitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Dermotologic Diseases and Immunologic Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Beijing Jishuitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Dermotologic Diseases and Immunologic Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuzi","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Beijing Jishuitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Dermotologic Diseases and Immunologic Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Beijing Jishuitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Dermotologic Diseases and Immunologic Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Beijing Jishuitan Hospital, Capital Medical University  Beijing China"},{"name":"National Clinical Research Center for Dermotologic Diseases and Immunologic Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Research Center Beijing Jishuitan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Research Center Beijing Jishuitan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"issue":"7","key":"e_1_2_10_2_1","first-page":"598","article-title":"Prevalence of psoriasis in China: an epidemiological survey in six provinces","volume":"24","author":"Ding XL","year":"2010","journal-title":"Chin J 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