{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:33:13Z","timestamp":1779370393091,"version":"3.53.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is observationally associated with a higher risk of complications of arthroplasty; however, the causal effects of psoriasis on complications of arthroplasty are yet to be established. This study was to explore the causal effect of psoriasis on artificial joint re\u2010operation after arthroplasty through two\u2010sample Mendelian randomization (MR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the MR analysis, psoriasis was selected as the exposure in this study while single\u2010nucleotide polymorphisms (SNPs) from a genome\u2010wide association study (GWAS) were selected as the instrumental variables (IVs). Summary statistics data on artificial joint re\u2010operation was extracted from publicly available GWAS data, including 218 792 European descent individuals. MR analysis was performed using the standard inverse variance weighted method (IVW). Furthermore, MR Egger, weighted median, simple mode, weighted mode, and the MR\u2010PRESSO (Mendelian Randomization Pleiotropy Residual Sum and Outlier) test were also done to verify the results. Finally, the sensitivity analysis was executed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IVW showed that psoriasis increases the risk of artificial joint re\u2010operation (OR\u00a0=\u00a01.12; 95% CI\u00a0=\u00a0(1.01, 1.25); <jats:italic>p<\/jats:italic>\u00a0=\u00a00.036). This outcome was also verified by other methods including weighted median (OR\u00a0=\u00a01.16; 95% CI\u00a0=\u00a0(1.03, 1.31); <jats:italic>p<\/jats:italic>\u00a0=\u00a00.015), MR Egger (OR\u00a0=\u00a01.22; 95% CI\u00a0=\u00a0(1.03, 1.44); <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038), and weighted mode (OR\u00a0=\u00a01.16; 95% CI\u00a0=\u00a0(1.03, 1.30); <jats:italic>p<\/jats:italic>\u00a0=\u00a00.025). No heterogeneity and directional pleiotropy were observed upon sensitivity analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study showed that psoriasis has a potential causal effect on artificial joint re\u2010operation after arthroplasty. Further studies are warranted to elucidate the underlying mechanisms of causal associations between psoriasis on re\u2010operation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13560","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T02:28:44Z","timestamp":1704680924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["RETRACTED: The causal relationship between psoriasis and artificial joint re\u2010operation after arthroplasty: A two\u2010sample Mendelian randomization study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5147-1660","authenticated-orcid":false,"given":"Hongzhi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Wangjing Hospital China Academy of Chinese Medical Sciences  Chaoyang Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqiu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuiqing","family":"Li","sequence":"additional","affiliation":[{"name":"Weifang Traditional Chinese Hospital  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Wangjing Hospital China Academy of Chinese Medical Sciences  Chaoyang Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,7]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1","volume-title":"National Joint Registry for England, Wales, Northern Ireland and the Isle of Man: 13th Annual Report","author":"NJR 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