{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:49:49Z","timestamp":1772898589555,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The lips play a significant role in shaping facial aesthetics. Due to the distinct attributes of lips in contrast to other facial skin, a unique approach is imperative for managing lip aging. We analyzed lip characteristics (morphology, wrinkles, and color) to investigate visual changes and distinctive attributes of aging lips.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>By utilizing image data processing methods, including facial landmark detection, pattern recognition, and color quantification, we extracted 11 lip characteristic indices (four morphological indices, four wrinkle indices, and three color indices) from high\u2010resolution images of 1000 Korean women aged 20\u201369. Correlation tests were conducted to assess the relationship between lip characteristic indices and age, and also between lip morphological and wrinkle indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lip height significantly decreased, while lip width and lip ratio (lip width divided by the sum of the upper and lower lip height) significantly increased with aging. Lip wrinkles significantly increased with aging, whereas lip colors (redness and yellowness) decreased. The lip wrinkle indices, which are segmented for the first time in this study, exhibited significant correlations with lip width, and three of them additionally were correlated with lip ratio (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The results imply such morphological changes can be associated with wrinkle formation of human lips.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The indices suggested in this study can be used for assessing lip aging characteristics, and the study results can contribute to deeper understanding of lip aging.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.13563","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:51:30Z","timestamp":1704847890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Image\u2010based investigation of lip aging features in a large number of Korean women"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-2974","authenticated-orcid":false,"given":"Jung Yeon","family":"Seo","sequence":"first","affiliation":[{"name":"Research and Innovation Center, R&amp;D Center LG H&amp;H  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9911-9279","authenticated-orcid":false,"given":"Sangseob","family":"Leem","sequence":"additional","affiliation":[{"name":"Research and Innovation Center, R&amp;D Center LG H&amp;H  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-6084","authenticated-orcid":false,"given":"Hanji","family":"Kim","sequence":"additional","affiliation":[{"name":"Research and Innovation Center, R&amp;D Center LG H&amp;H  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3786-418X","authenticated-orcid":false,"given":"Seung Won","family":"You","sequence":"additional","affiliation":[{"name":"Research and Innovation Center, R&amp;D Center LG H&amp;H  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1353-4784","authenticated-orcid":false,"given":"Yunkwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Research and Innovation Center, R&amp;D Center LG H&amp;H  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3318-3873","authenticated-orcid":false,"given":"Nae Gyu","family":"Kang","sequence":"additional","affiliation":[{"name":"Research and Innovation Center, R&amp;D Center LG H&amp;H  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010018\u20101268\u2010x"},{"key":"e_1_2_10_3_1","volume-title":"StatPearls. 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