{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:34:48Z","timestamp":1789918488995,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["822MS186"],"award-info":[{"award-number":["822MS186"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is a persistent inflammatory dermatological disorder. Tanshinone IIA (tan\u2010IIA) is a biologically active compound in the self\u2010made Xiao\u2010Yin decoction (SMXYD) and exhibits diverse biological properties, such as anti\u2010proliferative and anti\u2010inflammatory effects. The objective of this investigation was to assess the potential of tan\u2010IIA as a therapeutic agent against psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Network pharmacology was employed to ascertain the active constituents and potential pathways associated with SMXYD and psoriasis. We conducted CCK\u20108, qRT\u2010PCR, and western blotting to assess the proliferation of HaCaT keratinocytes and the expression of IL\u201017\/IL\u201023 and PTGS2\/NF\u2010\u03baB\/AP\u20101 pathways. Additionally, we used H&amp;E staining, western blotting, and ELISA to evaluate the therapeutic effects and signaling pathways of tan\u2010IIA in psoriasis\u2010like mice induced by imiquimod (IMQ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Network pharmacology analysis identified eight hub compounds. The Th17\/IL\u201017 signaling was found to be a potential therapeutic pathway of SMXYD against psoriasis, with JUN (AP\u20101) as the core molecule. Next, PTGS2 was selected as the target of tan\u2010IIA against psoriasis using network pharmacology analysis. Molecular docking showed a high affinity between PTGS2 and tan\u2010IIA. Tan\u2010IIA treatment attenuated M\u20105\u2010induced hyperproliferation and inflammation in HaCaT keratinocytes. Additionally, Tan\u2010IIA downregulated the PTGS2\/NF\u2010\u03baB\/AP\u20101 pathway in HaCaT keratinocytes. In the IMQ\u2010induced psoriasis\u2010like mouse, tan\u2010IIA significantly reduced the severity of skin lesions and downregulated the PTGS2\/NF\u2010\u03baB\/AP\u20101 pathway. Moreover, the combination of methotrexate (MTX) and tan\u2010IIA further inhibited the IL\u201017\/IL\u201023 and PTGS2\/NF\u2010\u03baB\/AP\u20101 pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The administration of tan\u2010IIA has shown a positive effect on psoriasis by inhibiting the IL\u201017\/IL\u201023 and PTGS2\/NF\u2010\u03baB\/AP\u20101 pathways. The findings suggest that it has promising qualities that make it a potential candidate for the development of future anti\u2010psoriatic agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13577","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T05:07:39Z","timestamp":1706504859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Tanshinone IIA, a component of the self\u2010made Xiao\u2010Yin decoction, ameliorates psoriasis by inhibiting IL\u201017\/IL\u201023 and PTGS2\/NF\u2010\u03baB\/AP\u20101 pathways"],"prefix":"10.1111","volume":"30","author":[{"given":"Lei","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Dermatology Hainan Hospital of Traditional Chinese Medicine  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of 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