{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:22:33Z","timestamp":1770834153148,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y2023568"],"award-info":[{"award-number":["Y2023568"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies have demonstrated the coexistence of erythema nodosum (EN) and inflammatory bowel disease (IBD), while the exact etiology of the co\u2010occurrence of the two disorders remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A bidirectional two\u2010sample Mendelian randomization (MR) design was employed to determine the causal link between EN and IBD. Genetic variations associated with Crohn's disease (CD) and ulcerative colitis (UC) were derived from accessible genome\u2010wide association studies pertaining to European ancestry. The FinnGen database was used to find the genetic variations containing EN. In the forward model, IBD was identified as the exposure, whereas in the reverse model, EN was identified as the exposure. The causal link between IBD and EN was examined using a range of different analysis techniques, the primary one being the inverse variance weighted (IVW) method, including inverse variance weighted\u2010fixed effects (IVW\u2010FE) and inverse\u2010variance weighted\u2010multiplicative random effects (IVW\u2010MRE). To strengthen the results, assessments of sensitivity, heterogeneity, and pleiotropy were also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MR results showed that IBD increased the risk of EN (IVW\u2010MRE: OR\u00a0=\u00a01.242, 95% CI\u00a0=\u00a01.068\u20131.443,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005). Furthermore, there was a strong correlation found between CD and a higher risk of EN (IVW\u2010FE: OR\u00a0=\u00a01.250, 95% CI\u00a0=\u00a01.119\u20131.396,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a08.036 \u00d7 10\n                      <jats:sup>\u22125<\/jats:sup>\n                      ). However, UC did not appear to be linked to EN (IVW\u2010FE: OR\u00a0=\u00a01.104, 95% CI\u00a0=\u00a00.868\u20131.405,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.421). The reverse MR analysis findings did not imply that EN was linked to IBD. Horizontal pleiotropy did not appear to exist, and the robustness of these findings was confirmed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current investigation found that in European populations, IBD and its subtype CD could raise the incidence of EN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13600","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T01:44:09Z","timestamp":1706751849000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Causal relationship between inflammatory bowel disease and erythema nodosum: A two\u2010sample bidirectional Mendelian randomization study"],"prefix":"10.1111","volume":"30","author":[{"given":"Haoqi","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"},{"name":"Department of Gastroenterology Wenzhou Central Hospital  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Second Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guolong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Second Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Second Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020831"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.150"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.07.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0156-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00634-6"},{"issue":"11","key":"e_1_2_9_7_1","article-title":"Interventions for the management of abdominal pain in Crohn's disease and inflammatory bowel 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