{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:13:25Z","timestamp":1790108005622,"version":"4.0.1"},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory bowel disease (IBD) and psoriasis (Ps) are common immune\u2010mediated diseases that exhibit clinical comorbidity, possibly due to a common genetic structure. However, the exact mechanism remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study population consisted of IBD and Ps genome\u2010wide association study (GWAS) data. Genetic correlations were first evaluated. Then, the overall evaluation employed LD score regression (LDSC), while the local assessment utilized heritability estimation from summary statistics (HESS). Causality assessment was conducted through two\u2010sample Mendelian randomization (2SMR), and genetic overlap analysis utilized the conditional false discovery rate\/conjunctional FDR (cond\/conjFDR) method. Finally, LDSC applied to specifically expressed genes (LDSC\u2010SEG) was performed at the tissue level. For IBD and Ps\u2010specific expressed genes, genetic correlation, causality, shared genetics, and trait\u2010specific associated tissues were methodically examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the genomic level, both overall and local genetic correlations were found between IBD and Ps. MR analysis indicated a positive causal relationship between Ps and IBD. The conjFDR analysis with a threshold of\u00a0&lt;\u00a00.01 identified 43 loci shared between IBD and Ps. Subsequent investigations into disease\u2010associated tissues indicated a close association of IBD and Ps with whole blood, lung, spleen, and EBV\u2010transformed lymphocytes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current research offers a novel perspective on the association between IBD and Ps. It contributes to an enhanced comprehension of the genetic structure and mechanisms of comorbidities in both diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13611","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T04:51:47Z","timestamp":1707799907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Evidence for the gut\u2010skin axis: Common genetic structures in inflammatory bowel disease and psoriasis"],"prefix":"10.1111","volume":"30","author":[{"given":"Jinyan","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Anorectal Surgery Jiangmen Wuyi Hospital of Traditional Chinese Medicine  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Luo","sequence":"additional","affiliation":[{"name":"Clinical Medical College Jiangxi University of Chinese Medicine  Nanchang 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