{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:46:47Z","timestamp":1793933207464,"version":"4.8.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009430","name":"Chanel Recherche et Technologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009430","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Facial dark spots remain a significant challenge for the cosmetic industry, in terms of providing effective treatment. Using Line\u2010field Confocal Optical Coherence Tomography (LC\u2010OCT), we investigated the internal structural features of photo\u2010aging spot areas and evaluated the efficacy of a skin\u2010brightening cosmetic product.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Twenty\u2010six Asian female volunteers, aged between 29 and 65 years, applied a cosmetic product on their entire face twice a day for 2 months. LC\u2010OCT was used to evaluate the dermal\u2010epidermal junction (DEJ) undulation and the volume density of melanin in the epidermis at D0 and D56. Skin brightening and redness were also assessed by photography (SkinCam).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Using LC\u2010OCT technology, various microscopic dark spot morphologies, spanning from minimally deformed DEJ to complex DEJ patterns, were identified. Dark spots characterized by slight deformities in the DEJ were predominantly observed in the youngest age group, while older volunteers displayed a wavier pattern. Furthermore, a total of 44 spots were monitored to evaluate the brightening product efficacy. A statistically significant reduction in melanin volumetric density of 7.3% in the spots and 12.3% in their surrounding area was observed after 56 days of product application. In line with these results, an analysis of color parameters using SkinCam reveals a significant increase in brightening and decrease in redness in both pigmented spots and the surrounding skin following application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LC\u2010OCT proves to be a valuable tool for in\u2010depth dark spots characterization and assessment of skin brightening products, enabling various applications in the field of dermatological sciences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13623","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T10:14:27Z","timestamp":1708596867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Skin dark spot mapping and evaluation of brightening product efficacy using Line\u2010field Confocal Optical Coherence Tomography (LC\u2010OCT)"],"prefix":"10.1111","volume":"30","author":[{"given":"Randa","family":"Jdid","sequence":"first","affiliation":[{"name":"Chanel Parfums Beaut\u00e9 Innovation Recherche et D\u00e9veloppement  Pantin France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Pedrazzani","sequence":"additional","affiliation":[{"name":"DAMAE Medical, Application Departement Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Chanel Parfums Beaut\u00e9 Innovation Recherche et D\u00e9veloppement  Pantin France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Fischman","sequence":"additional","affiliation":[{"name":"DAMAE Medical, Application Departement Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Cazorla","sequence":"additional","affiliation":[{"name":"Chanel Parfums Beaut\u00e9 Innovation Recherche et D\u00e9veloppement  Pantin France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Forestier","sequence":"additional","affiliation":[{"name":"Chanel Parfums Beaut\u00e9 Innovation Recherche et D\u00e9veloppement  Pantin France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youcef Ben","family":"Khalifa","sequence":"additional","affiliation":[{"name":"Chanel Parfums Beaut\u00e9 Innovation Recherche et D\u00e9veloppement  Pantin France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28031053"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2008.7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2023.02.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-32953-6_3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1990.tb16134.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151\u20109638(12)70126\u20106"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022\u2010202X.2005.23760.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303\u20106987.2004.00210.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.26.7.075002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101747.1999.00690.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13190"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12756"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201018657\u2010z"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11081498"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.385303"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12200\u2010020\u20101096\u2010x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16857"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202100236"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.23.10.106007"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.26.033534"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14051140"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12815"},{"key":"e_1_2_10_24_1","unstructured":"AyadhM AbellanM\u2010A FigueiredoS et\u00a0al.LC\u2010OCT imaging for studying the variation of morphological properties of human skin in vivo according to age and body area: the forearm and the thigh. 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