{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:35:53Z","timestamp":1773794153375,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Botulinum toxin injections are widely sought after in the field of medical aesthetics, offering consumers a variety of brand choices. Two commonly available botulinum toxin products, onabotulinumtoxinA and neubotulinumtoxinA, are featured in numerous clinics, leading many to question whether there are discernible differences in results, given their varying price ranges.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the efficacy and safety of neubotulinumtoxinA for the treatment of forehead horizontal lines.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A 12\u2010week prospective, single\u2010centre, interventional split\u2010face study was conducted, including 30 subjects. These enrolled subjects received a single treatment session, with neubotulinumtoxinA applied to the left side of the forehead and onabotulinumtoxinA to the right side. A superficial injection was performed in all individuals, where the product was injected subdermally in the frontalis muscle. Evaluation was conducted at baseline, 7 days, 14, days and 4, 8, and 12\u00a0weeks after treatment, both when the eyebrows were at maximum lift and in a resting position. Treatment efficacy was assessed by two physicians and self\u2010assessed by the patients, using the Fitzpatrick Wrinkle Classification system. Adverse events were documented to evaluate safety.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study found no statistically significant difference in the efficacy of neubotulinum and onabotulinum for treating forehead wrinkles, as indicated by\n p<\/jats:italic>\n \u2010values above 0.05 for both static and dynamic conditions. No safety and adverse events were observed in both formulations.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study has demonstrated that neither formulation is inferior to each other in the treatment of forehead horizontal lines.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/srt.13644","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T05:55:46Z","timestamp":1711518946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["RETRACTED: The efficacy and safety of neubotulinumtoxinA for the treatment of forehead horizontal lines in Asians \u2013 A clinical, prospective, interventional, split\u2010face study"],"prefix":"10.1111","volume":"30","author":[{"given":"Jessica Jane","family":"Sy","sequence":"first","affiliation":[{"name":"Asia\u2010Pacific Aesthetic Academy Seoul Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Wu","sequence":"additional","affiliation":[{"name":"Asia\u2010Pacific Aesthetic Academy Seoul Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovian","family":"Wan","sequence":"additional","affiliation":[{"name":"Division in Anatomy and Developmental Biology, Department of Oral Biology Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50\u20131 Yonsei\u2010ro, Seodaemun\u2010gu Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010Bin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division in Anatomy and Developmental Biology, Department of Oral Biology Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50\u20131 Yonsei\u2010ro, Seodaemun\u2010gu Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu\u2010Ho","family":"Yi","sequence":"additional","affiliation":[{"name":"Division in Anatomy and Developmental Biology, Department of Oral Biology Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50\u20131 Yonsei\u2010ro, Seodaemun\u2010gu Seoul South Korea"},{"name":"Maylin Clinic (Apgujeong) Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13040269"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.24004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins14040271"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.8.1059"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.321"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2021-102653"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-021-02813-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12463"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00482-2"},{"issue":"1","key":"e_1_2_8_12_1","first-page":"9s","article-title":"A review of onabotulinumtoxinA (Botox)","volume":"33","author":"Lorenc ZP","year":"2013","journal-title":"Aesthet Surg J"},{"key":"e_1_2_8_13_1","article-title":"Anatomical proposal for botulinum neurotoxin injection for horizontal forehead lines","author":"Yi KH","year":"2023","journal-title":"Plast Reconstr Surg"},{"key":"e_1_2_8_14_1","unstructured":"Minist\u00e9rio da Sa\u00fade Consultoria Jur\u00eddica\/Advocacia Geral da Uni\u00e3o 1 Nota T\u00e9cnica N\u00b0 Nota T\u00e9cnica N\u00b0342\/2014 [cited 2019 28 July]. Available from:https:\/\/portalarquivos2.saude.gov.br\/images\/pdf\/2014\/setembro\/17\/Toxina\u2010botul\u2013nica\u2010tipo\u2010A.pdf"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12073"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2009.23.3.137"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20450"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12070"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.31.20150175"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2009.00419.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000032496"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12595"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13309"},{"issue":"3","key":"e_1_2_8_24_1","first-page":"168","article-title":"Botulinum toxin injection for facial wrinkles","volume":"90","author":"Small R","year":"2014","journal-title":"Am Fam Physician"}],"updated-by":[{"DOI":"10.1111\/srt.70287","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000}},{"DOI":"10.1111\/srt.70287","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"record-id":"69798"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.13644","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:45:09Z","timestamp":1770911109000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,27]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/srt.13644"],"URL":"https:\/\/doi.org\/10.1111\/srt.13644","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,27]]},"assertion":[{"value":"2024-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13644"}}