{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:55:31Z","timestamp":1785423331943,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Considering the pathogenesis of psoriasis and also the anti\u2010oxidant, immunomodulatory, and anti\u2010inflammatory properties of rosuvastatin and melatonin, the current clinical trial aimed to evaluate the efficacy of topical rosuvastatin and melatonin in patients with mild to moderate psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The current randomized placebo\u2010controlled clinical trial was conducted using a 3\u2010arm parallel group included 77 adult patients (\u226518 years old) with mild to moderate plaque psoriasis.<\/jats:p>\n                    <jats:p>Patients were randomized into a 1:1:1 ratio to one of three groups to receive one of the three interventions: melatonin cream, 5.0% (w\/w), rosuvastatin cream, 5.0% (w\/w), or placebo cream with a similar transparent appearance twice a day for 12\u00a0weeks. The primary outcome was severity of the disease using Psoriasis Area Severity Index (PASI). The secondary outcomes included the Dermatological Sum Score (DSS) to assess the erythema, scaling, and plaque elevation and the Dermatology Life Quality Index (DLQI). Photographs of the lesions were also taken at the baseline and at different periodic intervals thereafter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 77 randomized patients, 52 (mean (SD) age, 40.67 (10.85) years; 22 (42.30%) men) completed the study. A significant reduction of 45% (mean (SD) of 2.67 (0.98) to 1.74 (1.12)) and 70% (mean (SD) of 2.67 (0.98) to 1.31 (1.13)) in PASI score, and 46% (mean (SD) of 2.91(1.85) to 1.57 (1.11)) and 77% (mean (SD) of 2.91 (1.85) to 0.87 (0.67)) in DSS score on days 30 and 60 with rosuvastatin cream, 5% w\/w (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) compared with baseline was observed, respectively.\n                    <\/jats:p>\n                    <jats:p>\n                      Also a significant decrease of 35% (mean (SD) of 2.67 (0.98) to 1.74 (1.12)) and 51% (mean (SD) of 2.67 (0.98) to 1.31 (1.13)) in PASI score, and 40% (mean (SD) of 5.00 (1.58) to 3.00 (1.76))and 61% (mean (SD) of 5.00 (1.58) to 1.92 (1.71)) in DSS score on days 30 and 60 with melatonin cream, 5% w\/w (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) compared with baseline were observed, respectively. In each of the melatonin or rosuvastatin groups, DLQI improved significantly on days 30 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) and 60 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) while the changes in the control group were not significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this clinical trial demonstrated that topical melatonin and rosuvastatin diminished the severity of mild to moderate plaque psoriasis with a satisfactory safety profile. Future clinical trials should assess both the long\u2010term efficacy and safety of melatonin and rosuvastatin creams in larger study populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13689","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T11:37:53Z","timestamp":1712057873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and safety of topical rosuvastatin &amp; melatonin vs. placebo in patients with mild to moderate plaque psoriasis: A preliminary randomized double\u2010blinded clinical trial"],"prefix":"10.1111","volume":"30","author":[{"given":"Farhad","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy Shahid Sadoughi University of Medical Sciences and Health Services  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh Zare","family":"Harofteh","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center School of Pharmacy Student Research Committee Shahid Sadoughi University of Medical Sciences and Health Services  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeleh","family":"Sahebnasagh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Clinical Research Center Faculty of Medicine North Khorasan University of Medical Sciences  Bojnurd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Ghaneei","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Shahid Sadoughi University of Medical Sciences and Health Services  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ebrahim Zadeh","family":"Ardakani","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Shahid Sadoughi University of Medical Sciences and Health Services  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4185-1341","authenticated-orcid":false,"given":"Fatemeh","family":"Saghafi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Pharmacy Shahid Sadoughi University of Medical Sciences and Health Services  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04332.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503023320907"},{"key":"e_1_2_11_4_1","first-page":"31","article-title":"Psoriasis: prevalence, spontaneous course, and genetics. 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