{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:46:30Z","timestamp":1783734390327,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Botulinum toxin is a crucial therapeutic tool with broad indications in both cosmetic and medical fields. However, the expanding cosmetic use and increased dosages of botulinum toxin have raised concerns about resistance, making it essential to study the awareness and management practices among healthcare professionals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A survey was conducted among clinical physicians using botulinum toxin. The study investigated their experiences, awareness, and management practices related to toxin resistance. Real\u2010time mobile app\u2010based surveys were administered to clinicians attending the 45th International Academic Conference of the Korean Academy of Laser and Dermatology (KALDAT) on December 3, 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 3140 participants, 673 clinical physicians completed the survey. Of these, 363 clinicians (53.9%) reported experiencing botulinum toxin resistance. Regarding the resistance rate, 59.4% indicated less than 1%, 36% reported approximately 1%\u201325%, and 95.4% reported less than 25%. Efforts to prevent resistance included maintaining intervals of over 3 months (54.8%), using products with lower resistance potential (47.0%), employing minimal effective doses (28.2%), and minimizing re\u2010administration (14.9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the South Korean aesthetic medicine community, a majority of clinical physician's report encountering botulinum toxin resistance. Given the potential loss of various benefits associated with resistance, there is a need to establish appropriate guidelines based on mechanistic studies and current status assessments. Educating clinicians on applicable guidelines is crucial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13691","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T02:13:57Z","timestamp":1712283237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Aesthetic doctors\u2019 perception and attitudes toward tolerance in botulinum toxin"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7949-4992","authenticated-orcid":false,"given":"Seung Min","family":"Oh","sequence":"first","affiliation":[{"name":"Gangnam ON Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung Moon","family":"Kim","sequence":"additional","affiliation":[{"name":"Maylin Clinic Ilsan Branch  Goyang\u2010si Gyeonggi\u2010do Republic of Korea"},{"name":"Department of Anatomy &amp; Cell Biology Gachon University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hwan","family":"Ahn","sequence":"additional","affiliation":[{"name":"Fresh Plastic Surgery Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Gangnam View Best Clinic  Pyeongtaek\u2010si Gyenggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo\u2010Seock","family":"Ree","sequence":"additional","affiliation":[{"name":"Gangnam View Best Clinic  Pyeongtaek\u2010si Gyenggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Soonchunhyang University Bucheon Hospital  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083259"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2013.09.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2011.00593.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12317"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000000507"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002320"},{"issue":"1","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/jocd.15513","article-title":"botulinum toxin for cosmetic treatments in young adults : an evidence based review and survey on current practice among aesthetic practitioners","volume":"22","author":"Michon A","journal-title":"J Cosmet 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