{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:29:02Z","timestamp":1773044942714,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Female pattern hair loss (FPHL) is the most prevalent type of alopecia among adult women. Presently, topical minoxidil stands as the sole treatment endorsed by the FDA. Addressing cases of FPHL in individuals who develop contact dermatitis in response to minoxidil can pose a challenge for dermatologists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the efficacy and safety of subcutaneous injections of Botulinum Toxin Type A (BTA) in treating FPHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Enrolled outpatients with FPHL who exhibited an allergic reaction to minoxidil solution. Diagnosis of FPHL was established through clinical examination and trichoscopy. Inclusion criteria involved patients with no prior treatment within the last year and without any comorbidities. BTA, specifically 100 units, was mixed with 2\u00a0mL of 0.9% normal saline. Twenty injection target sites, spaced 2\u20133\u00a0cm apart, were symmetrically marked on the hairless area of the scalp. A dosage of five units was intradermally injected at each target site. Representative photographs and dermoscopic images of the scalp were captured before and after 3\u00a0months of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 10 FPHL, aged between 26 and 40\u00a0years, were included. The average age was 30.3\u00a0\u00b1\u00a04.64\u00a0years, and all patients had a positive family history of Androgenetic Alopecia. The average duration of the disease was 3.70\u00a0\u00b1\u00a01.42\u00a0years. According to patients' self\u2010assessment, after 1\u00a0month of treatment, 10 FPHL patients reported experiencing moderate to marked improvement in symptoms related to scalp oil secretion. Three months later, dermatological assessments showed that three had mild improvement, six had no change, and one had a worsening condition. No adverse effects were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study suggests that the effectiveness of BTA for FPHL is limited to 3\u00a0months. However, it can be considered for tentative use after effective communication with patients. The long\u2010term efficacy and safety of BTA in treating FPHL require further observation and study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13696","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T06:50:57Z","timestamp":1712818257000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and safety of botulinum toxin A in the treatment of female pattern hair loss"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6535-4502","authenticated-orcid":false,"given":"Lifang","family":"Hu","sequence":"first","affiliation":[{"name":"The Department of Dermatology Hangzhou Third People's Hospital  Hangzhou City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YeQin","family":"Dai","sequence":"additional","affiliation":[{"name":"The Department of Dermatology Hangzhou Third People's Hospital  Hangzhou City China"},{"name":"Zhejiang University of Traditional Chinese Medicine affiliated Hangzhou Third People's Hospital  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Department of Dermatology Hangzhou Third People's Hospital  Hangzhou City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6969-4552","authenticated-orcid":false,"given":"Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"The Department of Dermatology Hangzhou Third People's Hospital  Hangzhou City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"The Department of Dermatology Hangzhou Third People's Hospital  Hangzhou City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzu","family":"Song","sequence":"additional","affiliation":[{"name":"The Department of Dermatology Hangzhou Third People's Hospital  Hangzhou City China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17079"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14055"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"189","article-title":"Female pattern hair loss: current treatment concepts","volume":"2","author":"Dinh QQ","year":"2007","journal-title":"Clin Intervent Aging"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13647"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181ef816d"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15179"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1501893"},{"key":"e_1_2_10_9_1","first-page":"163","article-title":"A pilot study to evaluate effectiveness of Botulinum toxin in treatment of androgenetic alopecia in males","volume":"10","author":"Singh S","year":"2018","journal-title":"J Cutan Aesthet 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