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The optimum doses of omalizumab remain controversial. Therefore, this study aims to estimate the efficacy and safety of different doses of omalizumab in the treatment of CIU patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Four databases were searched from the database's creation to April 8, 2023. Several keywords such as omalizumab and urticarias were used to retrieve related studies. The meta\u2010analytical outcomes were analyzed in R 4.2.1 software and Stata 15.1 software. Cochrane risk\u2010of\u2010bias tool Ver. 2 was used to evaluate the risk of bias in randomized controlled trials (RCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 2331 patients were included. Five indexes were employed to assess, including weekly Itch Severity Score (ISS7), weekly Hive Severity Score (HSS7), weekly Urticaria Activity Score (UAS7), Dermatology Life Quality Index (DLQI), and adverse events (AE). A 300\u00a0mg dose of omalizumab was the optimum dose to treat CIU, followed by the 150\u00a0mg dose. Furthermore, 600\u00a0mg of omalizumab only showed a significant difference from the placebo in HSS7. No significant statistical difference was observed in AE. Meta\u2010regression analysis revealed that time, as a covariate, was statistically significant in the comparison of omalizumab 150\u00a0mg with placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>300\u00a0mg of omalizumab was the optimum dosage to treat CIU patients, with a 150\u00a0mg dose also exhibiting good efficacy. Further studies are required to explore the efficacy and safety of different doses of omalizumab in the treatment of CIU patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13749","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T11:50:36Z","timestamp":1716378636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative efficacy and safety of the treatment by Omalizumab for chronic idiopathic urticaria in the general population: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Lan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of First Clinical Medical College Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Third 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