{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:31:40Z","timestamp":1788427900070,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Severe acne breakouts often lead to atrophic acne scars, which affect millions of people worldwide and can significantly affect a person's self\u2010confidence and self\u2010image. Given the difficulty in treating atrophic acne scars, this study aims to investigate the efficacy of topical phenytoin in the treatment of atrophic acne scars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This split face clinical trial on 25 patients between the ages of 18 and 40 involved the application of microneedling on one side of the face, with three sessions taking place over the course of a month. On the other side, a 1% phenytoin cream was administered three times daily for 1 week following the microneedling procedure. Baseline information was collected for all patients, and follow\u2010up assessments were conducted during the treatment sessions and 2 months after the last session. The assessments included evaluating the number and area of pores and spots, determining scar severity, assessing patient satisfaction, and recording any potential complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among patients, 20 individuals (80%) were females, and the average age of the participants was 35.96\u00a0\u00b1\u00a09.23. In terms of the fine pore area, despite the fine pore count, both groups showed improvement over time (\n                      <jats:italic>p<\/jats:italic>\n                      : 0.03\u00a0vs. 0.06). Also, regarding large pore count and area, and the count and area of spots, both groups showed improvement over time (\n                      <jats:italic>p<\/jats:italic>\n                      : 0.001). However, there were no significant differences between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a00.05). On the other hand, when it comes to acne scar grade and patients' satisfaction, the phenytoin group outperformed the control group in all follow\u2010up sessions and this difference was found to be significant (\n                      <jats:italic>p<\/jats:italic>\n                      : 0.001). It is worth noting that no complications were observed among any of the patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It appears that combining phenytoin cream with microneedling has a more effective therapeutic outcome in enhancing atrophic acne scars, when compared to microneedling alone, and this method can be regarded as a viable alternative in treating these types of scars.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13766","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T01:58:56Z","timestamp":1716947936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["RETRACTED: Evaluation and comparison of the efficacy and safety of the combination of topical phenytoin and microneedling with microneedling alone in the treatment of atrophic acne scars: A controlled blinded randomized clinical trial"],"prefix":"10.1111","volume":"30","author":[{"given":"Afsaneh","family":"Sadeghzadeh\u2010Bazargan","sequence":"first","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences (IUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arezoo","family":"Pashaei","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences (IUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Ghassemi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran 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Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences (IUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"313","article-title":"Assessment of depression in patients of acne vulgaris and its correlation with severity of acne, post acne scarring and gender","volume":"27","author":"Mishra N","year":"2017","journal-title":"J Pak Assoc 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