{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:45:37Z","timestamp":1772995537326,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertrophic scars (HS) are a common disfiguring condition in daily clinical encounters which brings a lot of anxieties and concerns to patients, but the treatment options of HS are limited. Black cloth ointment (BCO), as a cosmetic ointment applicable to facial scars, has shown promising therapeutic effects for facial scarring. However, the molecular mechanisms underlying its therapeutic effects remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Network pharmacology was first applied to analyze the major active components of BCO and the related signaling pathways. Subsequently, rabbit ear scar model was successfully established to determine the pharmacological effects of BCO and its active component \u03b2\u2010elemene on HS. Finally, the molecular mechanism of BCO and \u03b2\u2010elemene was analyzed by Western blot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Through the network pharmacology, it showed that \u03b2\u2010elemene was the main active ingredient of BCO, and it could significantly improve the pathological structure of HS and reduce collagen deposition. BCO and \u03b2\u2010elemene could increase the expression of ER stress\u2010related markers and promote the increase of apoptotic proteins in the Western blot experiment and induce the apoptosis of myofibroblasts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that the material basis for the scar\u2010improving effects of the BCO is \u03b2\u2010elemene, and cellular apoptosis is the key mechanism through which the BCO and \u03b2\u2010elemene exert their effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13791","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T06:40:02Z","timestamp":1718779202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of black cloth ointment on hypertrophic scar formation: An investigation using integrated network pharmacology and animal assay"],"prefix":"10.1111","volume":"30","author":[{"given":"Qin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1479-7914","authenticated-orcid":false,"given":"Huaxu","family":"Liu","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases Shandong First Medical University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changle","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathology Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.07.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.603187"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100557"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00474-x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14243"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101530"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12050678"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.004"},{"key":"e_1_2_10_10_1","first-page":"956","article-title":"Characteristics of Zhao Bingnan's Heibuyao Gao in treating scars [J]","volume":"38","author":"Cao 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