{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T16:28:06Z","timestamp":1788107286557,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>MicroRNAs (miRNAs) are small RNA molecules that play a regulatory role in various biological processes by acting as intracellular mediators. They hold great potential as therapeutic agents for targeting human disease pathways; however, there is still much to be uncovered about their mechanism of gene regulation. Alopecia areata (AA) is a commonly occurring inflammatory condition characterized by the infiltration of T cells that specifically target the anagen\u2010stage hair follicle. The limited understanding of its precise cellular mechanism may be the reason behind the scarcity of effective treatments for AA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The significance and function of hsa\u2010miR\u2010193a\u20105p as a genetic marker for AA and its potential influence on the advancement of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and methods<\/jats:title>\n                    <jats:p>A case\u2010control study comprised 77 individuals diagnosed with AA who were matched with 75 healthy controls. In order to measure the expression of miR\u2010200c\u20103p in both groups, the real\u2010time PCR technique was utilized. The prediction of suitable genes for hsa\u2010miR\u2010193a\u20105p, as well as the identification of pathways and gene\u2010gene interactions, were carried out using bioinformatic tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The levels of hsa\u2010miR\u2010193a\u20105p expression were notably elevated in AA patients in comparison to healthy controls. Our prediction suggests that the involvement of hsa\u2010miR\u2010193a\u20105p in the development of AA is significant due to its influence on the inositol phosphorylation pathway and the Phosphatidylinositol signaling system, achieved through its direct impact on the IPPK gene.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For the first time, our study demonstrates the significant over\u2010expression of a new miRNA, hsa\u2010miR\u2010193a\u20105p, in the blood of AA patients compared to controls, and highlights its impact on the IPPK gene and the inositol phosphorylation and Phosphatidylinositol signaling pathways, suggesting a potential therapeutic role for hsa\u2010miR\u2010193a\u20105p in AA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13800","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T08:24:43Z","timestamp":1719303883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The role of hsa\u2010miR\u2010193a\u20105p as an important factor for control of inositol in alopecia areata"],"prefix":"10.1111","volume":"30","author":[{"given":"Ahmed Ibrahim","family":"AbdElneam","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Department of Basic Medical Sciences, College of Medicine Shaqra University  Dawadmi Saudi Arabia"},{"name":"Molecular Genetics and Enzymology Department Human Genetics and Genome Research Institute, National Research Center  Dokki Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Saleh","family":"Al\u2010Dhubaibi","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, College of Medicine Shaqra University  Dawadmi Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6582-907X","authenticated-orcid":false,"given":"Saleh Salem","family":"Bahaj","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences Sana'a University  Sana'a Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada Farouk","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Sexology, Faculty of Medicine Suez Canal University  Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina Mohammed","family":"Atef","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Sexology, Faculty of Medicine Suez Canal University  Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.11"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23222.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17079"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430909"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065165"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.7.9.1387"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/527895"},{"key":"e_1_2_11_9_1","unstructured":"MiR\u2010125a targets effector programs to stabilize Treg\u2010mediated immune homeostasis\u2014PubMed.https:\/\/pubmed.ncbi.nlm.nih.gov\/25963922\/"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.04.015"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxx019"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.22.126"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.05.005"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1685"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13503"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3578"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2023.147703"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13424"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.1322"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15625"},{"key":"e_1_2_11_21_1","article-title":"Vitamin D receptor gene polymorphism ApaI as a predisposing factor for psoriasis and its relation with serum Vitamin D levels and psoriasis severity","volume":"14","author":"Alhetheli G","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3449"},{"key":"e_1_2_11_23_1","first-page":"22","article-title":"The association between forkhead box class O3A gene polymorphism and psoriasis and its relationship with psoriasis severity","volume":"15","author":"Elneam AIA","year":"2022","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2018.188"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13639"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.09.009"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14473"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2017.4"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12050602"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13030505"},{"key":"e_1_2_11_31_1","first-page":"9607","article-title":"High expression of Rap2A is associated with poor prognosis of patients with hepatocellular carcinoma","volume":"10","author":"Zheng X","year":"2017","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100409"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-022-0931-4"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176183"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.61.070192.001301"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2600313"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19928-x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2022.110465"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25273"},{"key":"e_1_2_11_40_1","unstructured":"\u6c5f\u5357\u8c2d\u6653\u98ce &NanJ T. X. \u57fa\u4e8eRNA-Seq\u7684\u6cb9\u8336\u79cd\u5b50\u03b1-\u4e9a\u9ebb\u9178\u4ee3\u8c22\u9014\u5f84\u53ca\u76f8\u5173\u57fa\u56e0\u5206\u6790. \u6797\u4e1a\u79d1\u5b662014;50:68\u201375."},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2013.12.023"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-022-03176-9"},{"key":"e_1_2_11_43_1","doi-asserted-by":"crossref","unstructured":"Relationship of Pantothenic Acid and Inositol to Alopecia in Mice\u2014D. W. Woolley 1941.https:\/\/journals.sagepub.com\/doi\/abs\/10.3181\/00379727\u201046\u201012065?journalCode=ebma","DOI":"10.3181\/00379727-46-12065"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590903015544"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-199707010-00002"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.26442\/20795696.2022.4.201824"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a015180"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.11.005"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13528"}],"updated-by":[{"DOI":"10.1111\/srt.70212","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000}}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.13800","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T20:56:49Z","timestamp":1769893009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/srt.13800"],"URL":"https:\/\/doi.org\/10.1111\/srt.13800","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]},"assertion":[{"value":"2024-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13800"}}