{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:35:20Z","timestamp":1788388520011,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The disruption of the microbial community or dysbiosis alters the functional composition, metabolic activity, and local distribution of the microbiota leading the development of acne. The aim of this study is to evaluate the effect of a lotion containing a biotechnological phytocomplex, niacinamide, and succinic acid in the bacterial diversity of subjects with truncal mild\u2010moderate acne and its clinical benefits due to microbiota changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Open, clinical study in 43 subjects with truncal mild\u2010moderate acne treated with a lotion for 8\u00a0weeks. Bacterial diversity was analyzed by\n                      <jats:italic>16S rRNA<\/jats:italic>\n                      gene sequencing of skin samples. Clinical effects were evaluated through IGA acne severity scale, biometric measurements, and safety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 56 days of product's use, an increase in richness alpha diversity was found (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005), with a decrease in\n                      <jats:italic>Cutibacterium acnes<\/jats:italic>\n                      relative abundance (66.43%\u00a0vs. 58.11%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009). The clinical results showed a decrease in IGA score (27.59% decrease;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001), the inflammatory lesions (52.12% decrease,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006) and erythema (18.33% decrease,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007), and desquamation index (63.83% decrease,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02). The responder analysis of the IGA score showed that 60.47% of patients improved by at least one point at day 56. The product was well tolerated along the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of the lotion on acneic skin was effective on rebalancing the microbiota, inhibiting biofilm formation and other virulence factors, reducing erythema and desquamation, and improving acne's severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13806","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:49:54Z","timestamp":1721782194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A new topical biotechnological phytocomplex for truncal mild\u2010moderate acne restores skin microbiota balance"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-1382","authenticated-orcid":false,"given":"Aurora","family":"Guerra\u2010Tapia","sequence":"first","affiliation":[{"name":"Universidad Complutense de Madrid (UCM) Consulta Dermat\u00f3logas Guerra  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5947-6888","authenticated-orcid":false,"given":"Helena","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio Reig Jofre S.A  Sant Joan Despi Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6871-2288","authenticated-orcid":false,"given":"Carlos","family":"Nieto","sequence":"additional","affiliation":[{"name":"Laboratorio Reig Jofre S.A  Sant Joan Despi Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2662-2081","authenticated-orcid":false,"given":"Carlos","family":"Ruiz Alonso","sequence":"additional","affiliation":[{"name":"Laboratorio Reig Jofre S.A  Sant Joan Despi Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Bermejo","sequence":"additional","affiliation":[{"name":"Laboratorio Reig Jofre S.A  Sant Joan Despi Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Carr\u00f3n","sequence":"additional","affiliation":[{"name":"Microomics Systems S.L  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9594-2938","authenticated-orcid":false,"given":"Sergio","family":"Garcia\u2010Segura","sequence":"additional","affiliation":[{"name":"Microomics Systems S.L  Barcelona 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